Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
Abstract Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular ide...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2020-05-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-020-00384-w |
| _version_ | 1797259477379973120 |
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| author | Heli Yang Xiaoxi Xu Xin Ran Yuping Ran |
| author_facet | Heli Yang Xiaoxi Xu Xin Ran Yuping Ran |
| author_sort | Heli Yang |
| collection | DOAJ |
| description | Abstract Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The “blackish-red dot” dermoscopic sign of the verrucous granuloma gradually resolved during the treatment. |
| first_indexed | 2024-04-24T23:10:03Z |
| format | Article |
| id | doaj.art-16ce2b49a15c4923ba4b2ea0ec3a5fd9 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-04-24T23:10:03Z |
| publishDate | 2020-05-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-16ce2b49a15c4923ba4b2ea0ec3a5fd92024-03-17T12:15:32ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722020-05-0110484785310.1007/s13555-020-00384-wSuccessful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and CryotherapyHeli Yang0Xiaoxi Xu1Xin Ran2Yuping Ran3Department of Dermatovenereology, West China Hospital, Sichuan UniversityDepartment of Dermatovenereology, West China Hospital, Sichuan UniversityDepartment of Dermatovenereology, West China Hospital, Sichuan UniversityDepartment of Dermatovenereology, West China Hospital, Sichuan UniversityAbstract Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The “blackish-red dot” dermoscopic sign of the verrucous granuloma gradually resolved during the treatment.https://doi.org/10.1007/s13555-020-00384-wBlackish-red dot signCandida tropicalisCandidal granulomaCryotherapyDermoscopyHyperthermia |
| spellingShingle | Heli Yang Xiaoxi Xu Xin Ran Yuping Ran Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy Dermatology and Therapy Blackish-red dot sign Candida tropicalis Candidal granuloma Cryotherapy Dermoscopy Hyperthermia |
| title | Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy |
| title_full | Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy |
| title_fullStr | Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy |
| title_full_unstemmed | Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy |
| title_short | Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy |
| title_sort | successful treatment of refractory candidal granuloma by itraconazole and terbinafine in combination with hyperthermia and cryotherapy |
| topic | Blackish-red dot sign Candida tropicalis Candidal granuloma Cryotherapy Dermoscopy Hyperthermia |
| url | https://doi.org/10.1007/s13555-020-00384-w |
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