An fNIRS investigation of novel expressed emotion stimulations in schizophrenia
Abstract Living in high expressed emotion (EE) environments tends to increase the relapse rate in schizophrenia (SZ). At present, the neural substrates responsible for high EE in SZ remain poorly understood. Functional near-infrared spectroscopy (fNIRS) may be of great use to quantitatively assess c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38057-1 |
| _version_ | 1797778882886107136 |
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| author | Cuiyan Wang Yueqian Zhang Lam Ghai Lim Weiqi Cao Wei Zhang Xiaoyang Wan Lijun Fan Ying Liu Xi Zhang Zengjie Tian Xiaojun Liu Xiuzhi Pan Yuan Zheng Riyu Pan Yilin Tan Zhisong Zhang Roger S. McIntyre Zhifei Li Roger C. M. Ho Tong Boon Tang |
| author_facet | Cuiyan Wang Yueqian Zhang Lam Ghai Lim Weiqi Cao Wei Zhang Xiaoyang Wan Lijun Fan Ying Liu Xi Zhang Zengjie Tian Xiaojun Liu Xiuzhi Pan Yuan Zheng Riyu Pan Yilin Tan Zhisong Zhang Roger S. McIntyre Zhifei Li Roger C. M. Ho Tong Boon Tang |
| author_sort | Cuiyan Wang |
| collection | DOAJ |
| description | Abstract Living in high expressed emotion (EE) environments tends to increase the relapse rate in schizophrenia (SZ). At present, the neural substrates responsible for high EE in SZ remain poorly understood. Functional near-infrared spectroscopy (fNIRS) may be of great use to quantitatively assess cortical hemodynamics and elucidate the pathophysiology of psychiatric disorders. In this study, we designed novel low- (positivity and warmth) and high-EE (criticism, negative emotion, and hostility) stimulations, in the form of audio, to investigate cortical hemodynamics. We used fNIRS to measure hemodynamic signals while participants listened to the recorded audio. Healthy controls (HCs, $$n=42$$ n = 42 ) showed increased hemodynamic activation in the major language centers across EE stimulations, with stronger activation in Wernicke’s area during the processing of negative emotional language. Compared to HCs, people with SZ ( $$n=41$$ n = 41 ) exhibited smaller hemodynamic activation in the major language centers across EE stimulations. In addition, people with SZ showed weaker or insignificant hemodynamic deactivation in the medial prefrontal cortex. Notably, hemodynamic activation in SZ was found to be negatively correlated with the negative syndrome scale score at high EE. Our findings suggest that the neural mechanisms in SZ are altered and disrupted, especially during negative emotional language processing. This supports the feasibility of using the designed EE stimulations to assess people who are vulnerable to high-EE environments, such as SZ. Furthermore, our findings provide preliminary evidence for future research on functional neuroimaging biomarkers for people with psychiatric disorders. |
| first_indexed | 2024-03-12T23:23:56Z |
| format | Article |
| id | doaj.art-16ce3b21e2fc4a3e8a21a88179b8de4d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T23:23:56Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-16ce3b21e2fc4a3e8a21a88179b8de4d2023-07-16T11:15:20ZengNature PortfolioScientific Reports2045-23222023-07-0113111110.1038/s41598-023-38057-1An fNIRS investigation of novel expressed emotion stimulations in schizophreniaCuiyan Wang0Yueqian Zhang1Lam Ghai Lim2Weiqi Cao3Wei Zhang4Xiaoyang Wan5Lijun Fan6Ying Liu7Xi Zhang8Zengjie Tian9Xiaojun Liu10Xiuzhi Pan11Yuan Zheng12Riyu Pan13Yilin Tan14Zhisong Zhang15Roger S. McIntyre16Zhifei Li17Roger C. M. Ho18Tong Boon Tang19Huaibei Normal UniversityHuaibei Mental Health CenterDepartment of Electrical and Robotics Engineering, School of Engineering, Monash University MalaysiaHuaibei Normal UniversityHuaibei Mental Health CenterHuaibei Normal UniversityHuaibei Normal UniversityHuaibei Normal UniversityHuaibei Mental Health CenterHuaibei Normal UniversityHuaibei Normal UniversityHuaibei Normal UniversityHuaibei Normal UniversityAnqing Normal UniversityHuaibei Normal UniversityHuaibei Normal UniversityMood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for DepressionInstitute for Health Innovation and Technology (iHealthtech), National University of SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of SingaporeCentre for Intelligent Signal and Imaging Research (CISIR), Universiti Teknologi PETRONASAbstract Living in high expressed emotion (EE) environments tends to increase the relapse rate in schizophrenia (SZ). At present, the neural substrates responsible for high EE in SZ remain poorly understood. Functional near-infrared spectroscopy (fNIRS) may be of great use to quantitatively assess cortical hemodynamics and elucidate the pathophysiology of psychiatric disorders. In this study, we designed novel low- (positivity and warmth) and high-EE (criticism, negative emotion, and hostility) stimulations, in the form of audio, to investigate cortical hemodynamics. We used fNIRS to measure hemodynamic signals while participants listened to the recorded audio. Healthy controls (HCs, $$n=42$$ n = 42 ) showed increased hemodynamic activation in the major language centers across EE stimulations, with stronger activation in Wernicke’s area during the processing of negative emotional language. Compared to HCs, people with SZ ( $$n=41$$ n = 41 ) exhibited smaller hemodynamic activation in the major language centers across EE stimulations. In addition, people with SZ showed weaker or insignificant hemodynamic deactivation in the medial prefrontal cortex. Notably, hemodynamic activation in SZ was found to be negatively correlated with the negative syndrome scale score at high EE. Our findings suggest that the neural mechanisms in SZ are altered and disrupted, especially during negative emotional language processing. This supports the feasibility of using the designed EE stimulations to assess people who are vulnerable to high-EE environments, such as SZ. Furthermore, our findings provide preliminary evidence for future research on functional neuroimaging biomarkers for people with psychiatric disorders.https://doi.org/10.1038/s41598-023-38057-1 |
| spellingShingle | Cuiyan Wang Yueqian Zhang Lam Ghai Lim Weiqi Cao Wei Zhang Xiaoyang Wan Lijun Fan Ying Liu Xi Zhang Zengjie Tian Xiaojun Liu Xiuzhi Pan Yuan Zheng Riyu Pan Yilin Tan Zhisong Zhang Roger S. McIntyre Zhifei Li Roger C. M. Ho Tong Boon Tang An fNIRS investigation of novel expressed emotion stimulations in schizophrenia Scientific Reports |
| title | An fNIRS investigation of novel expressed emotion stimulations in schizophrenia |
| title_full | An fNIRS investigation of novel expressed emotion stimulations in schizophrenia |
| title_fullStr | An fNIRS investigation of novel expressed emotion stimulations in schizophrenia |
| title_full_unstemmed | An fNIRS investigation of novel expressed emotion stimulations in schizophrenia |
| title_short | An fNIRS investigation of novel expressed emotion stimulations in schizophrenia |
| title_sort | fnirs investigation of novel expressed emotion stimulations in schizophrenia |
| url | https://doi.org/10.1038/s41598-023-38057-1 |
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