Transforming Growth Factor ß1 and Gap Junction Protein Alpha 4 Gene Heterogeneity in Relation to the Severity of Clinical Disease in Cystic Fibrosis

Transforming Growth Factor ß1 and Gap Junction Protein Alpha 4 Gene Heterogeneity in Relation to the Severity of Clinical Disease in Cystic Fibrosis

Background: High TGFβ1-producing variants cause severe clinical disease in F508del homozygous patients. Lately, we showed that a single nucleotide polymorphism (SNP), rs41266431, in the GJA4 gene modifies the disease severity of cystic fibrosis (CF). Our aim was to investigate whether the clinical p...

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Bibliographic Details
Main Authors: Joern Pascal Laubach, Michael Ludwig, Tabea Horn, Olaf Eickmeier, Christina Smaczny, Ralf Schubert, Stefan Zielen, Christof Majoor, Malik Aydin, Alexander Schnell, Sabina Schmitt-Grohé
Format: Article
Language:English
Published: IMR Press 2023-07-01
Series:Frontiers in Bioscience-Landmark
Subjects:
cystic fibrosis
transforming growth factor beta1
gap junction protein alpha 4
bronchial inflammation
f508del homozygous
gene–gene interaction
geno-/phenotype relation
precision medicine
Online Access:https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807138

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https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807138

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