Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.

Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.

Hypermethylation in the promoter region of the MGMT gene encoding the DNA repair protein O(6)-methylguanine-DNA methyltransferase is among the most important prognostic factors for patients with glioblastoma and predicts response to treatment with alkylating agents like temozolomide. Hence, the MGMT...

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Bibliographic Details
Main Authors: Arne Christians, Christian Hartmann, Axel Benner, Jochen Meyer, Andreas von Deimling, Michael Weller, Wolfgang Wick, Markus Weiler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302822?pdf=render

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http://europepmc.org/articles/PMC3302822?pdf=render

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