Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing
Kuniaki Otsuka,1,2 Shougo Murakami,3 Kiyotaka Okajima,4 Koichi Shibata,1 Yutaka Kubo,5 Denis G Gubin,6– 8 Larry A Beaty,2 Germaine Cornelissen2 1Tokyo Women’s Medical University, Tokyo, Japan; 2Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 3Department of Cardiovascular...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/appropriate-circadian-circasemidian-coupling-protects-blood-pressure-f-peer-reviewed-fulltext-article-CIA |
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| author | Otsuka K Murakami S Okajima K Shibata K Kubo Y Gubin DG Beaty LA Cornelissen G |
| author_facet | Otsuka K Murakami S Okajima K Shibata K Kubo Y Gubin DG Beaty LA Cornelissen G |
| author_sort | Otsuka K |
| collection | DOAJ |
| description | Kuniaki Otsuka,1,2 Shougo Murakami,3 Kiyotaka Okajima,4 Koichi Shibata,1 Yutaka Kubo,5 Denis G Gubin,6– 8 Larry A Beaty,2 Germaine Cornelissen2 1Tokyo Women’s Medical University, Tokyo, Japan; 2Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 3Department of Cardiovascular Medicine, Soseikai General Hospital, Kyoto, Japan; 4Cardiovascular Internal Medicine, Higashi Omiya General Hospital, Saitama, Japan; 5Department of Medicine, Machida Keisen Hospital, Tokyo, Japan; 6Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Medical University, Tyumen, 625023, Russia; 7Department of Biology, Medical University, Tyumen, 625023, Russia; 8Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, RussiaCorrespondence: Germaine Cornelissen, Halberg Chronobiology Center, University of Minnesota, MMC8609, 420 Delaware Street SE, Minneapolis, MN, 55455, USA, Email corne001@umn.edu.an Kuniaki Otsuka, Executive Medical Center, Totsuka Royal Clinic, Tokyo Women’s Medical University, Related Medical Facility, Sinjuku City, Tokyo, Japan, Email frtotk99@ba2.so-net.ne.jpBackground: Blood pressure (BP) variability is involved in the appraisal of threat and safety, and can serve as a potential marker of psychological resilience against stress. The relationship between biological rhythms of BP and resilience was cross-sectionally assessed by 7-day/24-hour chronobiologic screening in a rural Japanese community (Tosa), with focus on the 12-hour component and the “circadian-circasemidian coupling” of systolic (S) BP.Subjects and Methods: Tosa residents (N = 239, 147 women, 23– 74 years), free of anti-hypertensive medication, completed 7-day/24-hour ambulatory BP monitoring. The circadian-circasemidian coupling was determined individually by computing the difference between the circadian phase and the circasemidian morning-phase of SBP. Participants were classified into three groups: those with a short coupling interval of about 4.5 hours (Group A), those with an intermediate coupling interval of about 6.0 hours (Group B), and those with a long coupling interval of about 8.0 hours (Group C).Results: Residents of Group B who showed optimal circadian-circasemidian coordination had less pronounced morning and evening SBP surges, as compared to residents of Group A (10.82 vs 14.29 mmHg, P < 0.0001) and Group C (11.86 vs 15.21 mmHg, P < 0.0001), respectively. The incidence of morning or evening SBP surge was less in Group B than in Group A (P < 0.0001) or Group C (P < 0.0001). Group B residents showed highest measures of wellbeing and psychological resilience, assessed by good relation with friends (P < 0.05), life satisfaction (P < 0.05), and subjective happiness (P < 0.05). A disturbed circadian-circasemidian coupling was associated with elevated BP, dyslipidemia, arteriosclerosis and a depressive mood.Conclusion: The circadian-circasemidian coupling of SBP could serve as a new biomarker in clinical practice to guide precision medicine interventions aimed at achieving properly timed rhythms, and thereby resilience and wellbeing.Keywords: 7-day/24-hour chronobiologic screening, blood pressure, biological 12-hour rhythm, appropriate circadian-circasemidian coupling, circadian acrophase, 12-hour morning acrophase, morning blood pressure surge, evening blood pressure surge, human resilience, wellbeing |
| first_indexed | 2024-04-09T13:16:21Z |
| format | Article |
| id | doaj.art-16d26ce1a64f4b48a2b848112da58732 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-04-09T13:16:21Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-16d26ce1a64f4b48a2b848112da587322023-05-11T18:59:32ZengDove Medical PressClinical Interventions in Aging1178-19982023-05-01Volume 1875576983655Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and WellbeingOtsuka KMurakami SOkajima KShibata KKubo YGubin DGBeaty LACornelissen GKuniaki Otsuka,1,2 Shougo Murakami,3 Kiyotaka Okajima,4 Koichi Shibata,1 Yutaka Kubo,5 Denis G Gubin,6– 8 Larry A Beaty,2 Germaine Cornelissen2 1Tokyo Women’s Medical University, Tokyo, Japan; 2Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 3Department of Cardiovascular Medicine, Soseikai General Hospital, Kyoto, Japan; 4Cardiovascular Internal Medicine, Higashi Omiya General Hospital, Saitama, Japan; 5Department of Medicine, Machida Keisen Hospital, Tokyo, Japan; 6Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Medical University, Tyumen, 625023, Russia; 7Department of Biology, Medical University, Tyumen, 625023, Russia; 8Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, RussiaCorrespondence: Germaine Cornelissen, Halberg Chronobiology Center, University of Minnesota, MMC8609, 420 Delaware Street SE, Minneapolis, MN, 55455, USA, Email corne001@umn.edu.an Kuniaki Otsuka, Executive Medical Center, Totsuka Royal Clinic, Tokyo Women’s Medical University, Related Medical Facility, Sinjuku City, Tokyo, Japan, Email frtotk99@ba2.so-net.ne.jpBackground: Blood pressure (BP) variability is involved in the appraisal of threat and safety, and can serve as a potential marker of psychological resilience against stress. The relationship between biological rhythms of BP and resilience was cross-sectionally assessed by 7-day/24-hour chronobiologic screening in a rural Japanese community (Tosa), with focus on the 12-hour component and the “circadian-circasemidian coupling” of systolic (S) BP.Subjects and Methods: Tosa residents (N = 239, 147 women, 23– 74 years), free of anti-hypertensive medication, completed 7-day/24-hour ambulatory BP monitoring. The circadian-circasemidian coupling was determined individually by computing the difference between the circadian phase and the circasemidian morning-phase of SBP. Participants were classified into three groups: those with a short coupling interval of about 4.5 hours (Group A), those with an intermediate coupling interval of about 6.0 hours (Group B), and those with a long coupling interval of about 8.0 hours (Group C).Results: Residents of Group B who showed optimal circadian-circasemidian coordination had less pronounced morning and evening SBP surges, as compared to residents of Group A (10.82 vs 14.29 mmHg, P < 0.0001) and Group C (11.86 vs 15.21 mmHg, P < 0.0001), respectively. The incidence of morning or evening SBP surge was less in Group B than in Group A (P < 0.0001) or Group C (P < 0.0001). Group B residents showed highest measures of wellbeing and psychological resilience, assessed by good relation with friends (P < 0.05), life satisfaction (P < 0.05), and subjective happiness (P < 0.05). A disturbed circadian-circasemidian coupling was associated with elevated BP, dyslipidemia, arteriosclerosis and a depressive mood.Conclusion: The circadian-circasemidian coupling of SBP could serve as a new biomarker in clinical practice to guide precision medicine interventions aimed at achieving properly timed rhythms, and thereby resilience and wellbeing.Keywords: 7-day/24-hour chronobiologic screening, blood pressure, biological 12-hour rhythm, appropriate circadian-circasemidian coupling, circadian acrophase, 12-hour morning acrophase, morning blood pressure surge, evening blood pressure surge, human resilience, wellbeinghttps://www.dovepress.com/appropriate-circadian-circasemidian-coupling-protects-blood-pressure-f-peer-reviewed-fulltext-article-CIA7-day/24-hour chronobiologic screeningblood pressurebiological 12-hour rhythmappropriate circadian-circasemidian couplingcircadian acrophase12-hour morning acrophasemorning blood pressure surgeevening blood pressure surgehuman resiliencewellbeing |
| spellingShingle | Otsuka K Murakami S Okajima K Shibata K Kubo Y Gubin DG Beaty LA Cornelissen G Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing Clinical Interventions in Aging 7-day/24-hour chronobiologic screening blood pressure biological 12-hour rhythm appropriate circadian-circasemidian coupling circadian acrophase 12-hour morning acrophase morning blood pressure surge evening blood pressure surge human resilience wellbeing |
| title | Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing |
| title_full | Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing |
| title_fullStr | Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing |
| title_full_unstemmed | Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing |
| title_short | Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing |
| title_sort | appropriate circadian circasemidian coupling protects blood pressure from morning surge and promotes human resilience and wellbeing |
| topic | 7-day/24-hour chronobiologic screening blood pressure biological 12-hour rhythm appropriate circadian-circasemidian coupling circadian acrophase 12-hour morning acrophase morning blood pressure surge evening blood pressure surge human resilience wellbeing |
| url | https://www.dovepress.com/appropriate-circadian-circasemidian-coupling-protects-blood-pressure-f-peer-reviewed-fulltext-article-CIA |
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