A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience
Background: Hepatoblastoma (HB) is the most common childhood primary hepatic malignancy. The overall survival rate in patients with HB has reached more than 80% over the past decades. The poor prognostic and high-risk HB have been defined, but the treatment and cure of refractory or relapsed HB is s...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957221000619 |
| _version_ | 1818620008851308544 |
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| author | Jen-Yin Hou Ting-Chi Yeh Ting-Huan Huang Jin-Cherng Sheu Hsi-Che Liu |
| author_facet | Jen-Yin Hou Ting-Chi Yeh Ting-Huan Huang Jin-Cherng Sheu Hsi-Che Liu |
| author_sort | Jen-Yin Hou |
| collection | DOAJ |
| description | Background: Hepatoblastoma (HB) is the most common childhood primary hepatic malignancy. The overall survival rate in patients with HB has reached more than 80% over the past decades. The poor prognostic and high-risk HB have been defined, but the treatment and cure of refractory or relapsed HB is still an arduous task. Methods: The complete records of HB in patients under the age of 18 at the MacKay Memorial Hospital between 1990 and 2019 were examined. Results: The treatment results for 11 patients with refractory or relapsed HB are presented. The multi-modality treatment records were reviewed and the clinical characteristics associated with poor outcome included multifocal lesions, low α-fetoprotein, great vessel invasion and metastases. Delayed liver tumor surgery was carried out in eight cases. The median duration of follow-up for the 11 patients was 48.6 months (range 1.9 to 316.8 months). The 5-year and 10-year overall survival rate were 62.3% ± 15% (SE) and 49.9% ± 16.4% (SE), respectively. Most treatment-related toxicities were tolerable. The major concern during long term follow-up was irreversible high-frequency hearing loss. Conclusion: Patients with refractory/relapsed HB are still a thorny issue and more research is needed to improve the outcome. |
| first_indexed | 2024-12-16T17:46:33Z |
| format | Article |
| id | doaj.art-16d2d7aa368b4923ab7f7d1305d4869f |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-16T17:46:33Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-16d2d7aa368b4923ab7f7d1305d4869f2022-12-21T22:22:26ZengElsevierPediatrics and Neonatology1875-95722021-07-01624400405A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experienceJen-Yin Hou0Ting-Chi Yeh1Ting-Huan Huang2Jin-Cherng Sheu3Hsi-Che Liu4MacKay Medical College, New Taipei City, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Memorial Hospital, Taipei, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Children's Hospital, Taipei, TaiwanMacKay Medical College, New Taipei City, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Memorial Hospital, Taipei, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Children's Hospital, Taipei, TaiwanMacKay Medical College, New Taipei City, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Memorial Hospital, Taipei, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Children's Hospital, Taipei, TaiwanDivision of Pediatric Surgery, MacKay Memorial Hospital, Taipei, TaiwanMacKay Medical College, New Taipei City, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Memorial Hospital, Taipei, Taiwan; Division of Pediatric Hematology-Oncology, MacKay Children's Hospital, Taipei, Taiwan; Corresponding author. Division of Pediatric Hematology-Oncology, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.Background: Hepatoblastoma (HB) is the most common childhood primary hepatic malignancy. The overall survival rate in patients with HB has reached more than 80% over the past decades. The poor prognostic and high-risk HB have been defined, but the treatment and cure of refractory or relapsed HB is still an arduous task. Methods: The complete records of HB in patients under the age of 18 at the MacKay Memorial Hospital between 1990 and 2019 were examined. Results: The treatment results for 11 patients with refractory or relapsed HB are presented. The multi-modality treatment records were reviewed and the clinical characteristics associated with poor outcome included multifocal lesions, low α-fetoprotein, great vessel invasion and metastases. Delayed liver tumor surgery was carried out in eight cases. The median duration of follow-up for the 11 patients was 48.6 months (range 1.9 to 316.8 months). The 5-year and 10-year overall survival rate were 62.3% ± 15% (SE) and 49.9% ± 16.4% (SE), respectively. Most treatment-related toxicities were tolerable. The major concern during long term follow-up was irreversible high-frequency hearing loss. Conclusion: Patients with refractory/relapsed HB are still a thorny issue and more research is needed to improve the outcome.http://www.sciencedirect.com/science/article/pii/S1875957221000619α-fetoproteinhepatoblastomaliverrefractoryrelapse |
| spellingShingle | Jen-Yin Hou Ting-Chi Yeh Ting-Huan Huang Jin-Cherng Sheu Hsi-Che Liu A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience Pediatrics and Neonatology α-fetoprotein hepatoblastoma liver refractory relapse |
| title | A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience |
| title_full | A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience |
| title_fullStr | A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience |
| title_full_unstemmed | A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience |
| title_short | A retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma: A single institution experience |
| title_sort | retrospective study of clinical features and outcome in patients with refractory or recurrent hepatoblastoma a single institution experience |
| topic | α-fetoprotein hepatoblastoma liver refractory relapse |
| url | http://www.sciencedirect.com/science/article/pii/S1875957221000619 |
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