<it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients
<p>Abstract</p> <p>Amyloid β is an <it>in vitro </it>substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (<it>ABCB1</it>) gene, encoding for P-gp, is highly polymorphic and this may result in a chan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-09-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/1/1/13 |
| _version_ | 1818113993541156864 |
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| author | Frankfort Suzanne V Doodeman Valerie D Bakker Remco Tulner Linda R van Campen Jos PCM Smits Paul HM Beijnen Jos H |
| author_facet | Frankfort Suzanne V Doodeman Valerie D Bakker Remco Tulner Linda R van Campen Jos PCM Smits Paul HM Beijnen Jos H |
| author_sort | Frankfort Suzanne V |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Amyloid β is an <it>in vitro </it>substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (<it>ABCB1</it>) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent <it>ABCB1 </it>Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an elderly population and if these SNPs and haplotypes differ between patients with dementia and age-matched non-demented control patients. <it>ABCB1 </it>genotype, allele and haplotype frequencies were neither significantly different between patients with dementia and age-matched controls, nor between subgroups of different types of dementia nor age-matched controls. This study shows <it>ABCB1 </it>genotype frequencies to be comparable with described younger populations. To our knowledge this is the first study on <it>ABCB1 </it>genotypes in dementia. <it>ABCB1 </it>genotypes are presently not useful as a biomarker for dementia, as they were not significantly different between demented patients and age-matched control subjects.</p> |
| first_indexed | 2024-12-11T03:43:39Z |
| format | Article |
| id | doaj.art-16d3d435c7774ad68246f993e848fbc4 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-11T03:43:39Z |
| publishDate | 2006-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-16d3d435c7774ad68246f993e848fbc42022-12-22T01:22:05ZengBMCMolecular Neurodegeneration1750-13262006-09-01111310.1186/1750-1326-1-13<it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patientsFrankfort Suzanne VDoodeman Valerie DBakker RemcoTulner Linda Rvan Campen Jos PCMSmits Paul HMBeijnen Jos H<p>Abstract</p> <p>Amyloid β is an <it>in vitro </it>substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (<it>ABCB1</it>) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent <it>ABCB1 </it>Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an elderly population and if these SNPs and haplotypes differ between patients with dementia and age-matched non-demented control patients. <it>ABCB1 </it>genotype, allele and haplotype frequencies were neither significantly different between patients with dementia and age-matched controls, nor between subgroups of different types of dementia nor age-matched controls. This study shows <it>ABCB1 </it>genotype frequencies to be comparable with described younger populations. To our knowledge this is the first study on <it>ABCB1 </it>genotypes in dementia. <it>ABCB1 </it>genotypes are presently not useful as a biomarker for dementia, as they were not significantly different between demented patients and age-matched control subjects.</p>http://www.molecularneurodegeneration.com/content/1/1/13 |
| spellingShingle | Frankfort Suzanne V Doodeman Valerie D Bakker Remco Tulner Linda R van Campen Jos PCM Smits Paul HM Beijnen Jos H <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients Molecular Neurodegeneration |
| title | <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients |
| title_full | <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients |
| title_fullStr | <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients |
| title_full_unstemmed | <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients |
| title_short | <it>ABCB1 </it>genotypes and haplotypes in patients with dementia and age-matched non-demented control patients |
| title_sort | it abcb1 it genotypes and haplotypes in patients with dementia and age matched non demented control patients |
| url | http://www.molecularneurodegeneration.com/content/1/1/13 |
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