Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma
Abstract. Asthma is characterized by chronic airway inflammation and airway hyper-responsiveness. However, the differences in pathophysiology and phenotypic symptomology make a diagnosis of “asthma” too broad hindering individualized treatment. Four asthmatic inflammatory phenotypes have been identi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-07-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002456 |
| _version_ | 1797786204931883008 |
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| author | Yinhe Feng Xiaoyin Liu Yubin Wang Rao Du Hui Mao Lishao Guo |
| author_facet | Yinhe Feng Xiaoyin Liu Yubin Wang Rao Du Hui Mao Lishao Guo |
| author_sort | Yinhe Feng |
| collection | DOAJ |
| description | Abstract. Asthma is characterized by chronic airway inflammation and airway hyper-responsiveness. However, the differences in pathophysiology and phenotypic symptomology make a diagnosis of “asthma” too broad hindering individualized treatment. Four asthmatic inflammatory phenotypes have been identified based on inflammatory cell profiles in sputum: eosinophilic, neutrophilic, paucigranulocytic, and mixed-granulocytic. Paucigranulocytic asthma may be one of the most common phenotypes in stable asthmatic patients, yet it remains much less studied than the other inflammatory phenotypes. Understanding of paucigranulocytic asthma in terms of phenotypic discrimination, distribution, stability, surrogate biomarkers, underlying pathophysiology, clinical characteristics, and current therapies is fragmented, which impedes clinical management of patients. This review brings together existing knowledge and ongoing research about asthma phenotypes, with a focus on paucigranulocytic asthma, in order to present a comprehensive picture that may clarify specific inflammatory phenotypes and thus improve clinical diagnoses and disease management. |
| first_indexed | 2024-03-13T01:05:34Z |
| format | Article |
| id | doaj.art-16d40def13294e45b05aa68480161fa5 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-13T01:05:34Z |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-16d40def13294e45b05aa68480161fa52023-07-06T06:34:29ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-07-01136131513152210.1097/CM9.0000000000002456202307050-00001Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthmaYinhe FengXiaoyin LiuYubin WangRao DuHui MaoLishao GuoAbstract. Asthma is characterized by chronic airway inflammation and airway hyper-responsiveness. However, the differences in pathophysiology and phenotypic symptomology make a diagnosis of “asthma” too broad hindering individualized treatment. Four asthmatic inflammatory phenotypes have been identified based on inflammatory cell profiles in sputum: eosinophilic, neutrophilic, paucigranulocytic, and mixed-granulocytic. Paucigranulocytic asthma may be one of the most common phenotypes in stable asthmatic patients, yet it remains much less studied than the other inflammatory phenotypes. Understanding of paucigranulocytic asthma in terms of phenotypic discrimination, distribution, stability, surrogate biomarkers, underlying pathophysiology, clinical characteristics, and current therapies is fragmented, which impedes clinical management of patients. This review brings together existing knowledge and ongoing research about asthma phenotypes, with a focus on paucigranulocytic asthma, in order to present a comprehensive picture that may clarify specific inflammatory phenotypes and thus improve clinical diagnoses and disease management.http://journals.lww.com/10.1097/CM9.0000000000002456 |
| spellingShingle | Yinhe Feng Xiaoyin Liu Yubin Wang Rao Du Hui Mao Lishao Guo Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma Chinese Medical Journal |
| title | Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| title_full | Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| title_fullStr | Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| title_full_unstemmed | Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| title_short | Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| title_sort | delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma |
| url | http://journals.lww.com/10.1097/CM9.0000000000002456 |
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