Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles
AbstractCombining DNA damage repair inhibitors and chemotherapeutic agents is an emerging strategy in cancer treatment. In this study, we engineered the polycation nanoparticle (NP), which co-encapsulated DNA damage repair inhibitor Dbait and chemotherapeutic drug Docetaxel (Dtxl), using H1 nanopoly...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1703726 |
| _version_ | 1797788781448790016 |
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| author | Nianli Liu Jiayin Ji Hui Qiu Zhiying Shao Xin Wen Aoxing Chen Senbang Yao Xingying Zhang Hong Yao Longzhen Zhang |
| author_facet | Nianli Liu Jiayin Ji Hui Qiu Zhiying Shao Xin Wen Aoxing Chen Senbang Yao Xingying Zhang Hong Yao Longzhen Zhang |
| author_sort | Nianli Liu |
| collection | DOAJ |
| description | AbstractCombining DNA damage repair inhibitors and chemotherapeutic agents is an emerging strategy in cancer treatment. In this study, we engineered the polycation nanoparticle (NP), which co-encapsulated DNA damage repair inhibitor Dbait and chemotherapeutic drug Docetaxel (Dtxl), using H1 nanopolymer (folate–-polyethylenimine600–cyclodextrin), and the size of H1/Dbait/Dtxl was about 117 nm. We demonstrated that H1/Dbait/Dtxl enhanced the efficiency of radio-chemotherapy in prostate cancer cells by CCK-8 assay and colony-forming assay. Importantly, the improvement of radio-chemotherapy of H1/Dbait/Dtxl in prostate cancer was also validated in vivo, and the NP did not have a high toxicity profile. The results of immunohistochemistry and western blot supported that the improved therapeutic efficacy was through inhibiting DNA damage repair signalling pathway. Our study supports further investigations using NP to co-deliver DNA damage repair inhibitors and chemotherapeutics to improve the therapeutic efficacy of cancer. |
| first_indexed | 2024-03-13T01:41:25Z |
| format | Article |
| id | doaj.art-16d4aed98a0c413492153b94ef94723a |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-13T01:41:25Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-16d4aed98a0c413492153b94ef94723a2023-07-03T14:04:56ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148130531410.1080/21691401.2019.1703726Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticlesNianli Liu0Jiayin Ji1Hui Qiu2Zhiying Shao3Xin Wen4Aoxing Chen5Senbang Yao6Xingying Zhang7Hong Yao8Longzhen Zhang9Cancer Institute of Xuzhou Medical University, Xuzhou, ChinaDepartment of Internal Medicine, NO.731 Hospital of CASIC, Beijing, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Interventional Ultrasound, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaCancer Institute of Xuzhou Medical University, Xuzhou, ChinaCancer Institute of Xuzhou Medical University, Xuzhou, ChinaAbstractCombining DNA damage repair inhibitors and chemotherapeutic agents is an emerging strategy in cancer treatment. In this study, we engineered the polycation nanoparticle (NP), which co-encapsulated DNA damage repair inhibitor Dbait and chemotherapeutic drug Docetaxel (Dtxl), using H1 nanopolymer (folate–-polyethylenimine600–cyclodextrin), and the size of H1/Dbait/Dtxl was about 117 nm. We demonstrated that H1/Dbait/Dtxl enhanced the efficiency of radio-chemotherapy in prostate cancer cells by CCK-8 assay and colony-forming assay. Importantly, the improvement of radio-chemotherapy of H1/Dbait/Dtxl in prostate cancer was also validated in vivo, and the NP did not have a high toxicity profile. The results of immunohistochemistry and western blot supported that the improved therapeutic efficacy was through inhibiting DNA damage repair signalling pathway. Our study supports further investigations using NP to co-deliver DNA damage repair inhibitors and chemotherapeutics to improve the therapeutic efficacy of cancer.https://www.tandfonline.com/doi/10.1080/21691401.2019.1703726NanoparticleDNA damage repair inhibitorDbaitradiosensitizercastration-resistant prostate cancer |
| spellingShingle | Nianli Liu Jiayin Ji Hui Qiu Zhiying Shao Xin Wen Aoxing Chen Senbang Yao Xingying Zhang Hong Yao Longzhen Zhang Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles Artificial Cells, Nanomedicine, and Biotechnology Nanoparticle DNA damage repair inhibitor Dbait radiosensitizer castration-resistant prostate cancer |
| title | Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles |
| title_full | Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles |
| title_fullStr | Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles |
| title_full_unstemmed | Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles |
| title_short | Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles |
| title_sort | improving radio chemotherapy efficacy of prostate cancer by co deliverying docetaxel and dbait with biodegradable nanoparticles |
| topic | Nanoparticle DNA damage repair inhibitor Dbait radiosensitizer castration-resistant prostate cancer |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1703726 |
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