USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability

USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability

Summary: Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore. We show here that the deubiquitinase USP9X strengthens the SAC by...

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Bibliographic Details
Main Authors:	Agnieszka Skowyra, Lindsey A. Allan, Adrian T. Saurin, Paul R. Clarke
Format:	Article
Language:	English
Published:	Elsevier 2018-04-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124718304765

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