Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study
Abstract Background Systemic inflammation and handgrip weakness have been used to predict mortality in many cancers. The purpose of current study was to evaluate the association of co‐occurrence of inflammation indicators and handgrip weakness with overall survival (OS) of lung cancer (LC) patients...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5180 |
| _version_ | 1797903077796216832 |
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| author | Mengmeng Song Qi Zhang Chunhua Song Tong Liu Xi Zhang Guotian Ruan Meng Tang Xiaowei Zhang Hailun Xie Heyang Zhang Yizhong Ge Xiangrui Li Kangping Zhang Ming Yang Qinqin Li Xiaoyue Liu Shiqi Lin Yu Xu Bo Li Xiaogang Li Kunhua Wang Hongxia Xu Wei Li Hanping Shi |
| author_facet | Mengmeng Song Qi Zhang Chunhua Song Tong Liu Xi Zhang Guotian Ruan Meng Tang Xiaowei Zhang Hailun Xie Heyang Zhang Yizhong Ge Xiangrui Li Kangping Zhang Ming Yang Qinqin Li Xiaoyue Liu Shiqi Lin Yu Xu Bo Li Xiaogang Li Kunhua Wang Hongxia Xu Wei Li Hanping Shi |
| author_sort | Mengmeng Song |
| collection | DOAJ |
| description | Abstract Background Systemic inflammation and handgrip weakness have been used to predict mortality in many cancers. The purpose of current study was to evaluate the association of co‐occurrence of inflammation indicators and handgrip weakness with overall survival (OS) of lung cancer (LC) patients with good performance status. Methods The cutoff points for handgrip strength (HGS) and the four inflammation indicators were calculated using Maxstat. The time‐dependent receiver operating characteristic curve and C‐index were used to select optimal inflammation indicator for predicting OS of LC patients. The Cox proportional hazard regression model was used to calculate the hazard ratio (HR) of mortality. Kaplan–Meier curves were constructed to evaluate the association of indicators and the OS of LC patients. Results Among the 1951 patients, the mean ± standard deviation (SD) age was 60.6 ± 9.9 years, and 1300 (66.6%) patients were male. In patients with good performance status (PS), handgrip weakness (HR, 1.49; 95% confidence interval [95% CI], 1.30–1.70, p < 0.001) and low advanced lung cancer inflammation index (ALI) (HR, 2.05; 95%CI, 1.79–2.34, p < 0.001), high systemic immune‐inflammation index (SII) (HR, 1.91; 95%CI, 1.66–2.19, p < 0.001), high platelet: lymphocyte ratio (PLR) (HR, 1.60; 95%CI, 1.40–1.82, p < 0.001), or high neutrophil: lymphocyte ratio (NLR) (HR, 2.01; 95%CI, 1.76–2.30, p < 0.001) were associated with increased mortality risk of LC patients. ALI had better C‐index (0.624) and time‐AUC in the prediction of OS in LC patients with good PS than other three combinations. The co‐occurrence of handgrip weakness and low ALI more than doubled the risk of death in LC with good PS (HR, 2.44; 95% CI, 2.06–2.89, p < 0.001). Conclusion In LC patients who have good PS, patients with combined handgrip weakness and low ALI have the worst prognosis. The Trial Registration Number ChiCTR1800020329. |
| first_indexed | 2024-04-10T09:27:17Z |
| format | Article |
| id | doaj.art-16d76579921b4bcb829a723c0cbac0c1 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:27:17Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-16d76579921b4bcb829a723c0cbac0c12023-02-19T18:54:07ZengWileyCancer Medicine2045-76342023-02-011232818283010.1002/cam4.5180Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational studyMengmeng Song0Qi Zhang1Chunhua Song2Tong Liu3Xi Zhang4Guotian Ruan5Meng Tang6Xiaowei Zhang7Hailun Xie8Heyang Zhang9Yizhong Ge10Xiangrui Li11Kangping Zhang12Ming Yang13Qinqin Li14Xiaoyue Liu15Shiqi Lin16Yu Xu17Bo Li18Xiaogang Li19Kunhua Wang20Hongxia Xu21Wei Li22Hanping Shi23Department of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Epidemiology and Statistics Henan Key Laboratory of Tumor Epidemiology College of Public Health, Zhengzhou University Zhengzhou Henan ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaThe First Affiliated Hospital of Kunming Medical University Yunnan ChinaAffiliated Hospital of Yunnan University Kunming ChinaAffiliated Hospital of Yunnan University Kunming ChinaYunnan University Kunming ChinaDepartment of Nutrition Daping Hospital & Research Institute of Surgery, Third Military Medical University Chongqing ChinaCancer Center of the First Hospital of Jilin University Changchun ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaAbstract Background Systemic inflammation and handgrip weakness have been used to predict mortality in many cancers. The purpose of current study was to evaluate the association of co‐occurrence of inflammation indicators and handgrip weakness with overall survival (OS) of lung cancer (LC) patients with good performance status. Methods The cutoff points for handgrip strength (HGS) and the four inflammation indicators were calculated using Maxstat. The time‐dependent receiver operating characteristic curve and C‐index were used to select optimal inflammation indicator for predicting OS of LC patients. The Cox proportional hazard regression model was used to calculate the hazard ratio (HR) of mortality. Kaplan–Meier curves were constructed to evaluate the association of indicators and the OS of LC patients. Results Among the 1951 patients, the mean ± standard deviation (SD) age was 60.6 ± 9.9 years, and 1300 (66.6%) patients were male. In patients with good performance status (PS), handgrip weakness (HR, 1.49; 95% confidence interval [95% CI], 1.30–1.70, p < 0.001) and low advanced lung cancer inflammation index (ALI) (HR, 2.05; 95%CI, 1.79–2.34, p < 0.001), high systemic immune‐inflammation index (SII) (HR, 1.91; 95%CI, 1.66–2.19, p < 0.001), high platelet: lymphocyte ratio (PLR) (HR, 1.60; 95%CI, 1.40–1.82, p < 0.001), or high neutrophil: lymphocyte ratio (NLR) (HR, 2.01; 95%CI, 1.76–2.30, p < 0.001) were associated with increased mortality risk of LC patients. ALI had better C‐index (0.624) and time‐AUC in the prediction of OS in LC patients with good PS than other three combinations. The co‐occurrence of handgrip weakness and low ALI more than doubled the risk of death in LC with good PS (HR, 2.44; 95% CI, 2.06–2.89, p < 0.001). Conclusion In LC patients who have good PS, patients with combined handgrip weakness and low ALI have the worst prognosis. The Trial Registration Number ChiCTR1800020329.https://doi.org/10.1002/cam4.5180ECOGhandgrip weaknessinflammation indicatorslung cancerprognosis |
| spellingShingle | Mengmeng Song Qi Zhang Chunhua Song Tong Liu Xi Zhang Guotian Ruan Meng Tang Xiaowei Zhang Hailun Xie Heyang Zhang Yizhong Ge Xiangrui Li Kangping Zhang Ming Yang Qinqin Li Xiaoyue Liu Shiqi Lin Yu Xu Bo Li Xiaogang Li Kunhua Wang Hongxia Xu Wei Li Hanping Shi Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study Cancer Medicine ECOG handgrip weakness inflammation indicators lung cancer prognosis |
| title | Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study |
| title_full | Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study |
| title_fullStr | Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study |
| title_full_unstemmed | Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study |
| title_short | Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study |
| title_sort | handgrip weakness systemic inflammation indicators and overall survival in lung cancer patients with well performance status a large multicenter observational study |
| topic | ECOG handgrip weakness inflammation indicators lung cancer prognosis |
| url | https://doi.org/10.1002/cam4.5180 |
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