Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China.
From February to May, 2013, 132 human avian influenza H7N9 cases were identified in China resulting in 37 deaths. We developed a novel, simple and effective compartmental modeling framework for transmissions among (wild and domestic) birds as well as from birds to human, to infer important epidemiol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4257544?pdf=render |
| _version_ | 1811336738028650496 |
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| author | Ying-Hen Hsieh Jianhong Wu Jian Fang Yong Yang Jie Lou |
| author_facet | Ying-Hen Hsieh Jianhong Wu Jian Fang Yong Yang Jie Lou |
| author_sort | Ying-Hen Hsieh |
| collection | DOAJ |
| description | From February to May, 2013, 132 human avian influenza H7N9 cases were identified in China resulting in 37 deaths. We developed a novel, simple and effective compartmental modeling framework for transmissions among (wild and domestic) birds as well as from birds to human, to infer important epidemiological quantifiers, such as basic reproduction number for bird epidemic, bird-to-human infection rate and turning points of the epidemics, for the epidemic via human H7N9 case onset data and to acquire useful information regarding the bird-to-human transmission dynamics. Estimated basic reproduction number for infections among birds is 4.10 and the mean daily number of human infections per infected bird is 3.16*10-5 [3.08*10-5, 3.23*10-5]. The turning point of 2013 H7N9 epidemic is pinpointed at April 16 for bird infections and at April 9 for bird-to-human transmissions. Our result reveals very low level of bird-to-human infections, thus indicating minimal risk of widespread bird-to-human infections of H7N9 virus during the outbreak. Moreover, the turning point of the human epidemic, pinpointed at shortly after the implementation of full-scale control and intervention measures initiated in early April, further highlights the impact of timely actions on ending the outbreak. This is the first study where both the bird and human components of an avian influenza epidemic can be quantified using only the human case data. |
| first_indexed | 2024-04-13T17:43:57Z |
| format | Article |
| id | doaj.art-16dac696b7da4ba2a09b1bd5b4bc6edc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T17:43:57Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-16dac696b7da4ba2a09b1bd5b4bc6edc2022-12-22T02:37:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11183410.1371/journal.pone.0111834Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China.Ying-Hen HsiehJianhong WuJian FangYong YangJie LouFrom February to May, 2013, 132 human avian influenza H7N9 cases were identified in China resulting in 37 deaths. We developed a novel, simple and effective compartmental modeling framework for transmissions among (wild and domestic) birds as well as from birds to human, to infer important epidemiological quantifiers, such as basic reproduction number for bird epidemic, bird-to-human infection rate and turning points of the epidemics, for the epidemic via human H7N9 case onset data and to acquire useful information regarding the bird-to-human transmission dynamics. Estimated basic reproduction number for infections among birds is 4.10 and the mean daily number of human infections per infected bird is 3.16*10-5 [3.08*10-5, 3.23*10-5]. The turning point of 2013 H7N9 epidemic is pinpointed at April 16 for bird infections and at April 9 for bird-to-human transmissions. Our result reveals very low level of bird-to-human infections, thus indicating minimal risk of widespread bird-to-human infections of H7N9 virus during the outbreak. Moreover, the turning point of the human epidemic, pinpointed at shortly after the implementation of full-scale control and intervention measures initiated in early April, further highlights the impact of timely actions on ending the outbreak. This is the first study where both the bird and human components of an avian influenza epidemic can be quantified using only the human case data.http://europepmc.org/articles/PMC4257544?pdf=render |
| spellingShingle | Ying-Hen Hsieh Jianhong Wu Jian Fang Yong Yang Jie Lou Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. PLoS ONE |
| title | Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. |
| title_full | Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. |
| title_fullStr | Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. |
| title_full_unstemmed | Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. |
| title_short | Quantification of bird-to-bird and bird-to-human infections during 2013 novel H7N9 avian influenza outbreak in China. |
| title_sort | quantification of bird to bird and bird to human infections during 2013 novel h7n9 avian influenza outbreak in china |
| url | http://europepmc.org/articles/PMC4257544?pdf=render |
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