Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

Background/Aims: Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL),...

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Bibliographic Details
Main Authors: Ioana Alesutan, Katharina Musculus, Tatsiana Castor, Kousi Alzoubi, Jakob Voelkl, Florian Lang
Format: Article
Language:English
Published: Karger Publishers 2015-09-01
Series:Kidney & Blood Pressure Research
Subjects:
Phosphate
TGFß1
NFAT5
Vesicular pH
H+ pump
Alkaline phosphatase
Osteoinductive signaling
Calcification
Senescence
Online Access:http://www.karger.com/Article/FullText/368524

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