Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions
Abstract In‐depth understanding of intra‐ and postdialytic phosphate kinetics is important to adjust treatment regimens in hemodialysis. We aimed to modify and validate a three‐compartment phosphate kinetic model to individual patient data and assess the temporal robustness. Intradialytic phosphate...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15899 |
| _version_ | 1797375090927599616 |
|---|---|
| author | Sisse H. Laursen Lise Boel Lisbet Brandi Jeppe H. Christensen Peter Vestergaard Ole Kristian Hejlesen |
| author_facet | Sisse H. Laursen Lise Boel Lisbet Brandi Jeppe H. Christensen Peter Vestergaard Ole Kristian Hejlesen |
| author_sort | Sisse H. Laursen |
| collection | DOAJ |
| description | Abstract In‐depth understanding of intra‐ and postdialytic phosphate kinetics is important to adjust treatment regimens in hemodialysis. We aimed to modify and validate a three‐compartment phosphate kinetic model to individual patient data and assess the temporal robustness. Intradialytic phosphate samples were collected from the plasma and dialysate of 12 patients during two treatments (HD1 and HD2). 2‐h postdialytic plasma samples were collected in four of the patients. First, the model was fitted to HD1 samples from each patient to estimate the mass transfer coefficients. Second, the best fitted model in each patient case was validated on HD2 samples. The best model fits were determined from the coefficient of determination (R2) values. When fitted to intradialytic samples only, the median (interquartile range) R2 values were 0.985 (0.959–0.997) and 0.992 (0.984–0.994) for HD1 and HD2, respectively. When fitted to both intra‐ and postdialytic samples, the results were 0.882 (0.838–0.929) and 0.963 (0.951–0.976) for HD1 and HD2, respectively. Eight patients demonstrated a higher R2 value for HD2 than for HD1. The model seems promising to predict individual plasma phosphate in hemodialysis patients. The results also show good temporal robustness of the model. Further modifications and validation on a larger sample are needed. |
| first_indexed | 2024-03-08T19:17:11Z |
| format | Article |
| id | doaj.art-16dddb707bcb4671a901c659870c95b2 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T19:17:11Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-16dddb707bcb4671a901c659870c95b22023-12-27T03:58:32ZengWileyPhysiological Reports2051-817X2023-12-011124n/an/a10.14814/phy2.15899Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictionsSisse H. Laursen0Lise Boel1Lisbet Brandi2Jeppe H. Christensen3Peter Vestergaard4Ole Kristian Hejlesen5The Danish Diabetes Academy Odense University Hospital Odense DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkDepartment of Cardiology, Nephrology, and Endocrinology, Nordsjællands Hospital Hillerød DenmarkDepartment of Nephrology Aalborg University Hospital Aalborg DenmarkSteno Diabetes Center North Jutland Aalborg University Hospital Aalborg DenmarkDepartment of Health Science and Technology Aalborg University Aalborg DenmarkAbstract In‐depth understanding of intra‐ and postdialytic phosphate kinetics is important to adjust treatment regimens in hemodialysis. We aimed to modify and validate a three‐compartment phosphate kinetic model to individual patient data and assess the temporal robustness. Intradialytic phosphate samples were collected from the plasma and dialysate of 12 patients during two treatments (HD1 and HD2). 2‐h postdialytic plasma samples were collected in four of the patients. First, the model was fitted to HD1 samples from each patient to estimate the mass transfer coefficients. Second, the best fitted model in each patient case was validated on HD2 samples. The best model fits were determined from the coefficient of determination (R2) values. When fitted to intradialytic samples only, the median (interquartile range) R2 values were 0.985 (0.959–0.997) and 0.992 (0.984–0.994) for HD1 and HD2, respectively. When fitted to both intra‐ and postdialytic samples, the results were 0.882 (0.838–0.929) and 0.963 (0.951–0.976) for HD1 and HD2, respectively. Eight patients demonstrated a higher R2 value for HD2 than for HD1. The model seems promising to predict individual plasma phosphate in hemodialysis patients. The results also show good temporal robustness of the model. Further modifications and validation on a larger sample are needed.https://doi.org/10.14814/phy2.15899compartment modelingdialysishyperphosphatemiakineticsphosphate |
| spellingShingle | Sisse H. Laursen Lise Boel Lisbet Brandi Jeppe H. Christensen Peter Vestergaard Ole Kristian Hejlesen Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions Physiological Reports compartment modeling dialysis hyperphosphatemia kinetics phosphate |
| title | Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions |
| title_full | Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions |
| title_fullStr | Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions |
| title_full_unstemmed | Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions |
| title_short | Evaluation of a phosphate kinetics model in hemodialysis therapy—Assessment of the temporal robustness of model predictions |
| title_sort | evaluation of a phosphate kinetics model in hemodialysis therapy assessment of the temporal robustness of model predictions |
| topic | compartment modeling dialysis hyperphosphatemia kinetics phosphate |
| url | https://doi.org/10.14814/phy2.15899 |
| work_keys_str_mv | AT sissehlaursen evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions AT liseboel evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions AT lisbetbrandi evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions AT jeppehchristensen evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions AT petervestergaard evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions AT olekristianhejlesen evaluationofaphosphatekineticsmodelinhemodialysistherapyassessmentofthetemporalrobustnessofmodelpredictions |