Methamphetamine signals transcription of IL1β and TNFα in a reactive oxygen species-dependent manner and interacts with HIV-1 Tat to decrease antioxidant defense mechanisms

Methamphetamine signals transcription of IL1β and TNFα in a reactive oxygen species-dependent manner and interacts with HIV-1 Tat to decrease antioxidant defense mechanisms

Methamphetamine (Meth) abuse is a common HIV co-morbidity that is linked to aggravated Central Nervous System (CNS) inflammation, which accentuates HIV- associated neurological disorders, triggered both directly or indirectly by the drug. We used the well-established human innate immune macrophage c...

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Bibliographic Details
Main Authors: Liana V. Basova, Whitney Vien, Nikki Bortell, Julia A. Najera, Maria Cecilia Garibaldi Marcondes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Tat
methamphetamine
inflammation
reactive oxygen species
HIV
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.911060/full

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