Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China
To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8...
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MDPI AG
2014-06-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/6/6/2519 |
| _version_ | 1818616715950424064 |
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| author | Tiejun Zhang Ying Liu Yuyan Zhang Jun Wang Veenu Minhas Charles Wood Na He |
| author_facet | Tiejun Zhang Ying Liu Yuyan Zhang Jun Wang Veenu Minhas Charles Wood Na He |
| author_sort | Tiejun Zhang |
| collection | DOAJ |
| description | To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41–3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94–60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV. |
| first_indexed | 2024-12-16T16:54:13Z |
| format | Article |
| id | doaj.art-16e16353956e403ba55667451c9747af |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-16T16:54:13Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-16e16353956e403ba55667451c9747af2022-12-21T22:23:56ZengMDPI AGViruses1999-49152014-06-01662519253010.3390/v6062519v6062519Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, ChinaTiejun Zhang0Ying Liu1Yuyan Zhang2Jun Wang3Veenu Minhas4Charles Wood5Na He6Department of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, ChinaPutuo District Center for Disease Control and Prevention, Shanghai 200032, ChinaDepartment of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, ChinaNebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USANebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USADepartment of Epidemiology, School of Public Health, Fudan University, and The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, ChinaTo elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41–3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94–60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.http://www.mdpi.com/1999-4915/6/6/2519human herpesvirus 8hepatitis C virusdrug userprevalenceChina |
| spellingShingle | Tiejun Zhang Ying Liu Yuyan Zhang Jun Wang Veenu Minhas Charles Wood Na He Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China Viruses human herpesvirus 8 hepatitis C virus drug user prevalence China |
| title | Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China |
| title_full | Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China |
| title_fullStr | Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China |
| title_full_unstemmed | Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China |
| title_short | Seroprevalence of Human Herpesvirus 8 and Hepatitis C Virus among Drug Users in Shanghai, China |
| title_sort | seroprevalence of human herpesvirus 8 and hepatitis c virus among drug users in shanghai china |
| topic | human herpesvirus 8 hepatitis C virus drug user prevalence China |
| url | http://www.mdpi.com/1999-4915/6/6/2519 |
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