Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.631454/full |
| _version_ | 1818922065922621440 |
|---|---|
| author | Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin |
| author_facet | Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin |
| author_sort | Wenyuan Ma |
| collection | DOAJ |
| description | Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR in patients with MMD is limited. The focus of this subject was to explore the relationship between PLR and NLR in patients with newly diagnosed MMD.Patients and methods: A cross-sectional study was performed including 261 patients with diagnosed MMD for the first time who were enrolled from our hospital, from 24 March 2013 to 24 December 2018. The clinical characteristics were collected for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were showed.Results: The mean levels or median values (interquartile range) of PLR and NLR were 146.979 ± 51.203 and 2.241 (1.589–2.984), respectively. A significant positive correlation between PLR and NLR levels (P < 0.001) was showed by the univariate analysis. Furthermore, a non-linear relationship was detected between PLR and NLR by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant positive correlation between PLR and NLR when the PLR level was lower than 219.82 (β 0.012, 95% CI 0.005, 0.019; P = 0.001). PLR was also significantly positively associated with NLR when PLR concentrations were >219.82 (β 0.098, 95% CI 0.069, 0.128; P < 0.001).Conclusion: There seemed to be a positive association between PLR and NLR in patients with MMD. This may help to further explain the role of inflammation in the occurrence and progress of MMD. |
| first_indexed | 2024-12-20T01:47:37Z |
| format | Article |
| id | doaj.art-16e4a285d45c458eb600e2ba79261e59 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T01:47:37Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-16e4a285d45c458eb600e2ba79261e592022-12-21T19:57:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-11-011210.3389/fneur.2021.631454631454Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional StudyWenyuan Ma0Changmeng Cui1Song Feng2Genhua Li3Guangkui Han4Jilan Liu5Xianyun Qin6Yawei Hu7Mengjie Wang8Lu Zhang9Feng Jin10Clinical Medical College, Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaClinical Medical College, Jining Medical University, Jining, ChinaClinical Medical College, Jining Medical University, Jining, ChinaShandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, ChinaInflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR in patients with MMD is limited. The focus of this subject was to explore the relationship between PLR and NLR in patients with newly diagnosed MMD.Patients and methods: A cross-sectional study was performed including 261 patients with diagnosed MMD for the first time who were enrolled from our hospital, from 24 March 2013 to 24 December 2018. The clinical characteristics were collected for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were showed.Results: The mean levels or median values (interquartile range) of PLR and NLR were 146.979 ± 51.203 and 2.241 (1.589–2.984), respectively. A significant positive correlation between PLR and NLR levels (P < 0.001) was showed by the univariate analysis. Furthermore, a non-linear relationship was detected between PLR and NLR by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant positive correlation between PLR and NLR when the PLR level was lower than 219.82 (β 0.012, 95% CI 0.005, 0.019; P = 0.001). PLR was also significantly positively associated with NLR when PLR concentrations were >219.82 (β 0.098, 95% CI 0.069, 0.128; P < 0.001).Conclusion: There seemed to be a positive association between PLR and NLR in patients with MMD. This may help to further explain the role of inflammation in the occurrence and progress of MMD.https://www.frontiersin.org/articles/10.3389/fneur.2021.631454/fullmoyamoya diseaseinflammationassociationplatelet-to-lymphocyte rationeutrophil-to-lymphocyte ratio |
| spellingShingle | Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study Frontiers in Neurology moyamoya disease inflammation association platelet-to-lymphocyte ratio neutrophil-to-lymphocyte ratio |
| title | Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study |
| title_full | Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study |
| title_fullStr | Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study |
| title_full_unstemmed | Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study |
| title_short | Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study |
| title_sort | platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with newly diagnosed moyamoya disease a cross sectional study |
| topic | moyamoya disease inflammation association platelet-to-lymphocyte ratio neutrophil-to-lymphocyte ratio |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.631454/full |
| work_keys_str_mv | AT wenyuanma platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT changmengcui platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT songfeng platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT genhuali platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT guangkuihan platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT jilanliu platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT xianyunqin platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT yaweihu platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT mengjiewang platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT luzhang platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy AT fengjin platelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnewlydiagnosedmoyamoyadiseaseacrosssectionalstudy |