Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials
The phagocyte–microbe interactions in the immune system is a defense mechanism but when excessively or inappropriately deployed can harm host tissues and participate in the development of different non-immune and immune chronic inflammatory diseases such as autoimmune problems, allergies, some rheum...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-08-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2015.00655/full |
| _version_ | 1819292175780806656 |
|---|---|
| author | Ibrahim Jantan Waqas Ahmad Syed Nasir Abbas Bukhari |
| author_facet | Ibrahim Jantan Waqas Ahmad Syed Nasir Abbas Bukhari |
| author_sort | Ibrahim Jantan |
| collection | DOAJ |
| description | The phagocyte–microbe interactions in the immune system is a defense mechanism but when excessively or inappropriately deployed can harm host tissues and participate in the development of different non-immune and immune chronic inflammatory diseases such as autoimmune problems, allergies, some rheumatoid disorders, cancers and others. Immunodrugs include organic synthetics, biological agents such as cytokines and antibodies acting on single targets or pathways have been used to treat immune-related diseases but with limited success. Most of immunostimulants and immunosuppressants in clinical use are the cytotoxic drugs which possess serious side effects. There is a growing interest to use herbal medicines as multi-component agents to modulate the complex immune system in the prevention of infections rather than treating the immune-related diseases. Many therapeutic effects of plant extracts have been suggested to be due to their wide array of immunomodulatory effects and influence on the immune system of the human body. Phytochemicals such as flavonoids, polysaccharides, lactones, alkaloids, diterpenoids and glycosides, present in several plants, have been reported to be responsible for the plants immunomodulating properties. Thus the search for natural products of plant origin as new leads for development of potent and safe immunosuppressant and immunostimulant agents is gaining much major research interest. The present review will give an overview of widely investigated plant-derived compounds (curcumin, resveratrol, epigallocatechol-3-gallate, quercetin, colchicine, capsaicin, andrographolide, and genistein) which have exhibited potent effects on cellular and humoral immune functions in pre-clinical investigations and will highlight their clinical potential. |
| first_indexed | 2024-12-24T03:50:22Z |
| format | Article |
| id | doaj.art-16e4abea0d544e2f86f003339277dbd1 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-24T03:50:22Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-16e4abea0d544e2f86f003339277dbd12022-12-21T17:16:35ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2015-08-01610.3389/fpls.2015.00655158994Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trialsIbrahim JantanWaqas AhmadSyed Nasir Abbas BukhariThe phagocyte–microbe interactions in the immune system is a defense mechanism but when excessively or inappropriately deployed can harm host tissues and participate in the development of different non-immune and immune chronic inflammatory diseases such as autoimmune problems, allergies, some rheumatoid disorders, cancers and others. Immunodrugs include organic synthetics, biological agents such as cytokines and antibodies acting on single targets or pathways have been used to treat immune-related diseases but with limited success. Most of immunostimulants and immunosuppressants in clinical use are the cytotoxic drugs which possess serious side effects. There is a growing interest to use herbal medicines as multi-component agents to modulate the complex immune system in the prevention of infections rather than treating the immune-related diseases. Many therapeutic effects of plant extracts have been suggested to be due to their wide array of immunomodulatory effects and influence on the immune system of the human body. Phytochemicals such as flavonoids, polysaccharides, lactones, alkaloids, diterpenoids and glycosides, present in several plants, have been reported to be responsible for the plants immunomodulating properties. Thus the search for natural products of plant origin as new leads for development of potent and safe immunosuppressant and immunostimulant agents is gaining much major research interest. The present review will give an overview of widely investigated plant-derived compounds (curcumin, resveratrol, epigallocatechol-3-gallate, quercetin, colchicine, capsaicin, andrographolide, and genistein) which have exhibited potent effects on cellular and humoral immune functions in pre-clinical investigations and will highlight their clinical potential.https://www.frontiersin.org/article/10.3389/fpls.2015.00655/fullimmunomodulationcurcuminresveratrolepigallocatechol-3-gallatequercetincolchicine |
| spellingShingle | Ibrahim Jantan Waqas Ahmad Syed Nasir Abbas Bukhari Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials Frontiers in Plant Science immunomodulation curcumin resveratrol epigallocatechol-3-gallate quercetin colchicine |
| title | Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials |
| title_full | Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials |
| title_fullStr | Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials |
| title_full_unstemmed | Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials |
| title_short | Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials |
| title_sort | plant derived immunomodulators an insight on their preclinical evaluation and clinical trials |
| topic | immunomodulation curcumin resveratrol epigallocatechol-3-gallate quercetin colchicine |
| url | https://www.frontiersin.org/article/10.3389/fpls.2015.00655/full |
| work_keys_str_mv | AT ibrahimjantan plantderivedimmunomodulatorsaninsightontheirpreclinicalevaluationandclinicaltrials AT waqasahmad plantderivedimmunomodulatorsaninsightontheirpreclinicalevaluationandclinicaltrials AT syednasirabbasbukhari plantderivedimmunomodulatorsaninsightontheirpreclinicalevaluationandclinicaltrials |