Structure–Activity Relationship of the Dimeric and Oligomeric Forms of a Cytotoxic Biotherapeutic Based on Diphtheria Toxin

Structure–Activity Relationship of the Dimeric and Oligomeric Forms of a Cytotoxic Biotherapeutic Based on Diphtheria Toxin

Protein aggregation is a well-recognized problem in industrial preparation, including biotherapeutics. These low-energy states constantly compete with a native-like conformation, which is more pronounced in the case of macromolecules of low stability in the solution. A better understanding of the st...

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Bibliographic Details
Main Authors: Marcin Mielecki, Marcin Ziemniak, Magdalena Ozga, Radosław Borowski, Jarosław Antosik, Angelika Kaczyńska, Beata Pająk
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
biotherapeutics
cytotoxin
diphtheria toxin
IL-13
inclusion bodies
refolding
Online Access:https://www.mdpi.com/2218-273X/12/8/1111

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