Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients
<p>Abstract</p> <p>Background</p> <p>Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined.</p> <...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-03-01
|
| Series: | Infectious Agents and Cancer |
| Online Access: | http://www.infectagentscancer.com/content/5/1/6 |
| _version_ | 1818233091046506496 |
|---|---|
| author | Bisson Gregory Nkomazana Oathokwa Steenhoff Andrew P Feldman Michael Murakami Masanao Simbiri Kenneth O Robertson Erle S |
| author_facet | Bisson Gregory Nkomazana Oathokwa Steenhoff Andrew P Feldman Michael Murakami Masanao Simbiri Kenneth O Robertson Erle S |
| author_sort | Bisson Gregory |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined.</p> <p>Results</p> <p>Tissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive. None of the patients were JC or BK positive. <it>In situ </it>hybridization and immunohistochemistry analyses further identified HPV, EBV, and KSHV in a subset of the tissue samples.</p> <p>Conclusion</p> <p>We identified the known oncogenic viruses HPV, KSHV, and EBV in OSSN and pterygia tissues. The presence of these tumor viruses in OSSN suggests that they may contribute to the development of this malignancy in the HIV population. Further studies are necessary to characterize the molecular mechanisms associated with viral antigens and their potential role in the development of OSSN.</p> |
| first_indexed | 2024-12-12T11:16:40Z |
| format | Article |
| id | doaj.art-16e6e4ec86ea421ab2db66e42f542ce1 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-12T11:16:40Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-16e6e4ec86ea421ab2db66e42f542ce12022-12-22T00:26:08ZengBMCInfectious Agents and Cancer1750-93782010-03-0151610.1186/1750-9378-5-6Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patientsBisson GregoryNkomazana OathokwaSteenhoff Andrew PFeldman MichaelMurakami MasanaoSimbiri Kenneth ORobertson Erle S<p>Abstract</p> <p>Background</p> <p>Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined.</p> <p>Results</p> <p>Tissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive. None of the patients were JC or BK positive. <it>In situ </it>hybridization and immunohistochemistry analyses further identified HPV, EBV, and KSHV in a subset of the tissue samples.</p> <p>Conclusion</p> <p>We identified the known oncogenic viruses HPV, KSHV, and EBV in OSSN and pterygia tissues. The presence of these tumor viruses in OSSN suggests that they may contribute to the development of this malignancy in the HIV population. Further studies are necessary to characterize the molecular mechanisms associated with viral antigens and their potential role in the development of OSSN.</p>http://www.infectagentscancer.com/content/5/1/6 |
| spellingShingle | Bisson Gregory Nkomazana Oathokwa Steenhoff Andrew P Feldman Michael Murakami Masanao Simbiri Kenneth O Robertson Erle S Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients Infectious Agents and Cancer |
| title | Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients |
| title_full | Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients |
| title_fullStr | Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients |
| title_full_unstemmed | Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients |
| title_short | Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients |
| title_sort | multiple oncogenic viruses identified in ocular surface squamous neoplasia in hiv 1 patients |
| url | http://www.infectagentscancer.com/content/5/1/6 |
| work_keys_str_mv | AT bissongregory multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT nkomazanaoathokwa multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT steenhoffandrewp multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT feldmanmichael multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT murakamimasanao multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT simbirikennetho multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients AT robertsonerles multipleoncogenicvirusesidentifiedinocularsurfacesquamousneoplasiainhiv1patients |