Neuregulins in Neurodegenerative Diseases
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions. Neuregulins (NRGs...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.662474/full |
| _version_ | 1818411003163967488 |
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| author | Guan-yong Ou Wen-wen Lin Wei-jiang Zhao Wei-jiang Zhao |
| author_facet | Guan-yong Ou Wen-wen Lin Wei-jiang Zhao Wei-jiang Zhao |
| author_sort | Guan-yong Ou |
| collection | DOAJ |
| description | Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions. Neuregulins (NRGs) belong to the epidermal growth factor (EGF)-like family of extracellular ligands and they play an important role in the development, maintenance, and repair of both the central nervous system (CNS) and peripheral nervous system (PNS) through the ErbB signaling pathway. They also regulate multiple intercellular signal transduction and participate in a wide range of biological processes, such as differentiation, migration, and myelination. In this review article, we summarized research on the changes and roles of NRGs in neurodegenerative diseases, especially in AD. We elaborated on the structural features of each NRG subtype and roles of NRG/ErbB signaling networks in neurodegenerative diseases. We also discussed the therapeutic potential of NRGs in the symptom remission of neurodegenerative diseases, which may offer hope for advancing related treatment. |
| first_indexed | 2024-12-14T10:24:30Z |
| format | Article |
| id | doaj.art-16e8e41fab9d41a79d2a2a019114d9f8 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T10:24:30Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-16e8e41fab9d41a79d2a2a019114d9f82022-12-21T23:06:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-04-011310.3389/fnagi.2021.662474662474Neuregulins in Neurodegenerative DiseasesGuan-yong Ou0Wen-wen Lin1Wei-jiang Zhao2Wei-jiang Zhao3Center for Neuroscience, Shantou University Medical College, Shantou, ChinaCenter for Neuroscience, Shantou University Medical College, Shantou, ChinaCenter for Neuroscience, Shantou University Medical College, Shantou, ChinaCell Biology Department, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaNeurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions. Neuregulins (NRGs) belong to the epidermal growth factor (EGF)-like family of extracellular ligands and they play an important role in the development, maintenance, and repair of both the central nervous system (CNS) and peripheral nervous system (PNS) through the ErbB signaling pathway. They also regulate multiple intercellular signal transduction and participate in a wide range of biological processes, such as differentiation, migration, and myelination. In this review article, we summarized research on the changes and roles of NRGs in neurodegenerative diseases, especially in AD. We elaborated on the structural features of each NRG subtype and roles of NRG/ErbB signaling networks in neurodegenerative diseases. We also discussed the therapeutic potential of NRGs in the symptom remission of neurodegenerative diseases, which may offer hope for advancing related treatment.https://www.frontiersin.org/articles/10.3389/fnagi.2021.662474/fullneuregulinErbB receptorneurodegenerationneurodegenerative diseasestreatment |
| spellingShingle | Guan-yong Ou Wen-wen Lin Wei-jiang Zhao Wei-jiang Zhao Neuregulins in Neurodegenerative Diseases Frontiers in Aging Neuroscience neuregulin ErbB receptor neurodegeneration neurodegenerative diseases treatment |
| title | Neuregulins in Neurodegenerative Diseases |
| title_full | Neuregulins in Neurodegenerative Diseases |
| title_fullStr | Neuregulins in Neurodegenerative Diseases |
| title_full_unstemmed | Neuregulins in Neurodegenerative Diseases |
| title_short | Neuregulins in Neurodegenerative Diseases |
| title_sort | neuregulins in neurodegenerative diseases |
| topic | neuregulin ErbB receptor neurodegeneration neurodegenerative diseases treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.662474/full |
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