Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes
Catalyst recovery is a major challenge for reaching the objectives of green chemistry for industry. Indeed, catalysts enable quick and selective syntheses with high reaction yields. This is especially the case for homogeneous platinoid catalysts which are almost indispensable for cross-coupling reac...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/13/8/738 |
| _version_ | 1797583876740087808 |
|---|---|
| author | Adrien Magne Emilie Carretier Lilivet Ubiera Ruiz Thomas Clair Morgane Le Hir Philippe Moulin |
| author_facet | Adrien Magne Emilie Carretier Lilivet Ubiera Ruiz Thomas Clair Morgane Le Hir Philippe Moulin |
| author_sort | Adrien Magne |
| collection | DOAJ |
| description | Catalyst recovery is a major challenge for reaching the objectives of green chemistry for industry. Indeed, catalysts enable quick and selective syntheses with high reaction yields. This is especially the case for homogeneous platinoid catalysts which are almost indispensable for cross-coupling reactions often used by the pharmaceutical industry. However, they are based on scarce, expensive, and toxic resources. In addition, they are quite sensitive and degrade over time at the end of the reaction. Once degraded, their regeneration is complex and hazardous to implement. Working on their recovery could lead to highly effective catalytic chemistries while limiting the environmental and economic impacts of their one-time uses. This review aims to describe and compare conventional processes for metal removal while discussing their advantages and drawbacks considering the objective of homogeneous catalyst recovery. Most of them lead to difficulty recycling active catalysts due to their ability to only treat metal ions or to chelate catalysts without the possibility to reverse the mechanism. However, membrane processes seem to offer some perspectives with limiting degradations. While membranes are not systematically the best option for recycling homogeneous catalysts, current development might help improve the separation between pharmaceutical active ingredients and catalysts and enable their recycling. |
| first_indexed | 2024-03-10T23:44:18Z |
| format | Article |
| id | doaj.art-16ea4e8aac204742aeaac63dad3df06e |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T23:44:18Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-16ea4e8aac204742aeaac63dad3df06e2023-11-19T02:08:08ZengMDPI AGMembranes2077-03752023-08-0113873810.3390/membranes13080738Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane ProcessesAdrien Magne0Emilie Carretier1Lilivet Ubiera Ruiz2Thomas Clair3Morgane Le Hir4Philippe Moulin5Aix Marseille Univ., CNRS, Centrale Marseille, M2P2 UMR 7340, Equipe Procédés Membranaires (EPM), Europole de l’Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix en Provence Cedex, FranceAix Marseille Univ., CNRS, Centrale Marseille, M2P2 UMR 7340, Equipe Procédés Membranaires (EPM), Europole de l’Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix en Provence Cedex, FranceSanofi Chimie, Laboratoire Génie des Procédés 1, Process Engineering, Global Chemistry Manufacturing & Control (CMC), 45 Chemin de Mételine, 04200 Sisteron, FranceSanofi Chimie, Laboratoire Génie des Procédés 1, Process Engineering, Global Chemistry Manufacturing & Control (CMC), 45 Chemin de Mételine, 04200 Sisteron, FranceSanofi Chimie, Laboratoire Génie des Procédés 1, Process Engineering, Global Chemistry Manufacturing & Control (CMC), 45 Chemin de Mételine, 04200 Sisteron, FranceAix Marseille Univ., CNRS, Centrale Marseille, M2P2 UMR 7340, Equipe Procédés Membranaires (EPM), Europole de l’Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix en Provence Cedex, FranceCatalyst recovery is a major challenge for reaching the objectives of green chemistry for industry. Indeed, catalysts enable quick and selective syntheses with high reaction yields. This is especially the case for homogeneous platinoid catalysts which are almost indispensable for cross-coupling reactions often used by the pharmaceutical industry. However, they are based on scarce, expensive, and toxic resources. In addition, they are quite sensitive and degrade over time at the end of the reaction. Once degraded, their regeneration is complex and hazardous to implement. Working on their recovery could lead to highly effective catalytic chemistries while limiting the environmental and economic impacts of their one-time uses. This review aims to describe and compare conventional processes for metal removal while discussing their advantages and drawbacks considering the objective of homogeneous catalyst recovery. Most of them lead to difficulty recycling active catalysts due to their ability to only treat metal ions or to chelate catalysts without the possibility to reverse the mechanism. However, membrane processes seem to offer some perspectives with limiting degradations. While membranes are not systematically the best option for recycling homogeneous catalysts, current development might help improve the separation between pharmaceutical active ingredients and catalysts and enable their recycling.https://www.mdpi.com/2077-0375/13/8/738platinoidhomogenous catalystmetal recoveryorganic solventmembranes |
| spellingShingle | Adrien Magne Emilie Carretier Lilivet Ubiera Ruiz Thomas Clair Morgane Le Hir Philippe Moulin Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes Membranes platinoid homogenous catalyst metal recovery organic solvent membranes |
| title | Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes |
| title_full | Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes |
| title_fullStr | Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes |
| title_full_unstemmed | Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes |
| title_short | Recovery of Homogeneous Platinoid Catalysts from Pharmaceutical Media: Review on the Existing Treatments and the Perspectives of Membrane Processes |
| title_sort | recovery of homogeneous platinoid catalysts from pharmaceutical media review on the existing treatments and the perspectives of membrane processes |
| topic | platinoid homogenous catalyst metal recovery organic solvent membranes |
| url | https://www.mdpi.com/2077-0375/13/8/738 |
| work_keys_str_mv | AT adrienmagne recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses AT emiliecarretier recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses AT lilivetubieraruiz recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses AT thomasclair recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses AT morganelehir recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses AT philippemoulin recoveryofhomogeneousplatinoidcatalystsfrompharmaceuticalmediareviewontheexistingtreatmentsandtheperspectivesofmembraneprocesses |