CD99–PTPN12 Axis Suppresses Actin Cytoskeleton-Mediated Dimerization of Epidermal Growth Factor Receptor

CD99–PTPN12 Axis Suppresses Actin Cytoskeleton-Mediated Dimerization of Epidermal Growth Factor Receptor

The epidermal growth factor receptor (EGFR), a member of ErbB receptor tyrosine kinase (RTK) family, is activated through growth factor-induced reorganization of the actin cytoskeleton and subsequent dimerization. We herein explored the molecular mechanism underlying the suppression of ligand-induce...

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Bibliographic Details
Main Authors:	Kyoung-Jin Lee, Yuri Kim, Min Seo Kim, Hyun-Mi Ju, Boyoung Choi, Hansoo Lee, Dooil Jeoung, Ki-Won Moon, Dongmin Kang, Jiwon Choi, Jong In Yook, Jang-Hee Hahn
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Cancers
Subjects:	actin cytoskeletal reorganization breast cancer CD99 agonist EGFR dimerization endocytosis FAK dephosphorylation
Online Access:	https://www.mdpi.com/2072-6694/12/10/2895

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