The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis
Background: At present, Chinese herbal medicine (CHM) has already been widely used as an important adjuvant treatment for polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization-embryo transfer (IVF-ET). This systematic review and meta-analysis were designed to evaluate the effec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805166 |
| _version_ | 1828747968506757120 |
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| author | Chang Liu Minchen Dai Lei Zhao Fangfang Wang |
| author_facet | Chang Liu Minchen Dai Lei Zhao Fangfang Wang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | Background: At present, Chinese herbal medicine (CHM) has already been widely used as an important adjuvant treatment for polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization-embryo transfer (IVF-ET). This systematic review and meta-analysis were designed to evaluate the effects of CHM on the pregnancy outcomes of infertile women with PCOS undergoing IVF-ET. Methods: We searched seven electronic databases systematically for published articles to January 2021. All randomized controlled trials (RCTs) comparing CHM with blank or placebo for infertile PCOS patients undergoing IVF-ET were included. The measures of treatment effect were the pooled odds ratios (OR) of the clinical pregnancy rate, the abortion rate and the ovarian hyperstimulation syndrome (OHSS) incidence. Results: This meta-analysis included 10 studies involving 663 patients comparing CHM with blank or placebo for infertile PCOS patients undergoing IVF-ET. The pooled data showed that CHM could improve the clinical pregnancy rate (OR = 2.41, 95% CI: 1.73–3.35, p < 0.01) and reduce the OHSS incidence (OR = 0.31, 95% CI: 0.18–0.55, p < 0.01) of infertile PCOS patients with IVF-ET treatment. No significant difference in the abortion rate was found between the CHM and control groups (OR = 0.64, 95% CI: 0.23–1.81, p = 0.40). Discussion: CHM can be used as an auxiliary treatment for infertile PCOS patients undergoing IVF-ET. |
| first_indexed | 2024-04-14T04:52:43Z |
| format | Article |
| id | doaj.art-16ee72846b654f0db64047a6ac2312f9 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-14T04:52:43Z |
| publishDate | 2021-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-16ee72846b654f0db64047a6ac2312f92022-12-22T02:11:14ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-10-014851032104310.31083/j.ceog4805166S0390-6663(21)00006-3The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysisChang Liu0Minchen Dai1Lei Zhao2Fangfang Wang3The Second Department of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, ChinaDepartment of Traditional Chinese Medicine, Women’s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaThe Second Department of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, ChinaDepartment of Obstetrics and Gynecology, Women’s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaBackground: At present, Chinese herbal medicine (CHM) has already been widely used as an important adjuvant treatment for polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization-embryo transfer (IVF-ET). This systematic review and meta-analysis were designed to evaluate the effects of CHM on the pregnancy outcomes of infertile women with PCOS undergoing IVF-ET. Methods: We searched seven electronic databases systematically for published articles to January 2021. All randomized controlled trials (RCTs) comparing CHM with blank or placebo for infertile PCOS patients undergoing IVF-ET were included. The measures of treatment effect were the pooled odds ratios (OR) of the clinical pregnancy rate, the abortion rate and the ovarian hyperstimulation syndrome (OHSS) incidence. Results: This meta-analysis included 10 studies involving 663 patients comparing CHM with blank or placebo for infertile PCOS patients undergoing IVF-ET. The pooled data showed that CHM could improve the clinical pregnancy rate (OR = 2.41, 95% CI: 1.73–3.35, p < 0.01) and reduce the OHSS incidence (OR = 0.31, 95% CI: 0.18–0.55, p < 0.01) of infertile PCOS patients with IVF-ET treatment. No significant difference in the abortion rate was found between the CHM and control groups (OR = 0.64, 95% CI: 0.23–1.81, p = 0.40). Discussion: CHM can be used as an auxiliary treatment for infertile PCOS patients undergoing IVF-ET.https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805166in vitro fertilization-embryo transferchinese herbal medicinepolycystic ovary syndrome |
| spellingShingle | Chang Liu Minchen Dai Lei Zhao Fangfang Wang The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis Clinical and Experimental Obstetrics & Gynecology in vitro fertilization-embryo transfer chinese herbal medicine polycystic ovary syndrome |
| title | The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis |
| title_full | The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis |
| title_fullStr | The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis |
| title_full_unstemmed | The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis |
| title_short | The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis |
| title_sort | effects of chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization embryo transfer a systematic review and meta analysis |
| topic | in vitro fertilization-embryo transfer chinese herbal medicine polycystic ovary syndrome |
| url | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805166 |
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