Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia
There is a paucity of reports examining the relationship between the integrity of the corpus callosum (CC) and different aspects of cognitive functioning in patients with first-episode (FES) and chronic schizophrenia (CS) simultaneously; furthermore, what results exist are inconclusive. We used diff...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/14/3158 |
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| author | Ernest Tyburski Piotr Podwalski Katarzyna Waszczuk Katarzyna Rek-Owodziń Monika Mak Piotr Plichta Maksymilian Bielecki Krzysztof Rudkowski Michał Szelepajło Jolanta Kucharska-Mazur Wojciech Andrusewicz Błażej Misiak Magdalena Kerestey Adrianna Bober Krzysztof Wietrzyński Anna Michalczyk Magdalena Więdłocha Piotr Marcinowicz Jerzy Samochowiec Leszek Sagan |
| author_facet | Ernest Tyburski Piotr Podwalski Katarzyna Waszczuk Katarzyna Rek-Owodziń Monika Mak Piotr Plichta Maksymilian Bielecki Krzysztof Rudkowski Michał Szelepajło Jolanta Kucharska-Mazur Wojciech Andrusewicz Błażej Misiak Magdalena Kerestey Adrianna Bober Krzysztof Wietrzyński Anna Michalczyk Magdalena Więdłocha Piotr Marcinowicz Jerzy Samochowiec Leszek Sagan |
| author_sort | Ernest Tyburski |
| collection | DOAJ |
| description | There is a paucity of reports examining the relationship between the integrity of the corpus callosum (CC) and different aspects of cognitive functioning in patients with first-episode (FES) and chronic schizophrenia (CS) simultaneously; furthermore, what results exist are inconclusive. We used diffusion tensor imaging tractography to investigate differences in integrity in five regions of the CC between FES, CS, and healthy controls (HC). Additionally, we analyzed correlations between these regions’ integrity and working memory, planning, and speed of processing. Eighteen patients with FES, 55 patients with CS, and 30 HC took part in the study. We assessed cognitive functions with four tasks from Measurement and Treatment Research to Improve Cognition in Schizophrenia. Patients with CS showed lower fractional anisotropy (FA) in Region 5 (statistical trend) and higher mean diffusivity (MD) in Regions 4 and 5 than HC, and patients with FES had higher MD in Region 3 (statistical trend) than HC. Both clinical groups performed worse on working memory and speed of processing tasks than HC, and patients with CS scored worse than HC on independent planning, and worse than FES and HC on dependent planning. Moreover, in patients with CS, MD in Region 3 was correlated with verbal working memory. Our results suggest that patients with FES and CS are characterized by impaired integrity of the middle and posterior CC, respectively. We confirmed that both clinical groups have cognitive impairments. Moreover, the integrity of the middle CC may influence planning in patients with CS. |
| first_indexed | 2024-03-10T09:35:01Z |
| format | Article |
| id | doaj.art-16eef5dddc22455eaa41944cf29dc03e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:35:01Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-16eef5dddc22455eaa41944cf29dc03e2023-11-22T04:07:37ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011014315810.3390/jcm10143158Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic SchizophreniaErnest Tyburski0Piotr Podwalski1Katarzyna Waszczuk2Katarzyna Rek-Owodziń3Monika Mak4Piotr Plichta5Maksymilian Bielecki6Krzysztof Rudkowski7Michał Szelepajło8Jolanta Kucharska-Mazur9Wojciech Andrusewicz10Błażej Misiak11Magdalena Kerestey12Adrianna Bober13Krzysztof Wietrzyński14Anna Michalczyk15Magdalena Więdłocha16Piotr Marcinowicz17Jerzy Samochowiec18Leszek Sagan19Institute of Psychology, SWPS University of Social Sciences and Humanities, 61-719 Poznań, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Neurosurgery, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandDepartment of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, 50-367 Wroclaw, PolandInstitute of Psychology, University of Szczecin, 71-017 Szczecin, PolandInstitute of Psychology, University of Szczecin, 71-017 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University in Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University in Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Neurosurgery, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandThere is a paucity of reports examining the relationship between the integrity of the corpus callosum (CC) and different aspects of cognitive functioning in patients with first-episode (FES) and chronic schizophrenia (CS) simultaneously; furthermore, what results exist are inconclusive. We used diffusion tensor imaging tractography to investigate differences in integrity in five regions of the CC between FES, CS, and healthy controls (HC). Additionally, we analyzed correlations between these regions’ integrity and working memory, planning, and speed of processing. Eighteen patients with FES, 55 patients with CS, and 30 HC took part in the study. We assessed cognitive functions with four tasks from Measurement and Treatment Research to Improve Cognition in Schizophrenia. Patients with CS showed lower fractional anisotropy (FA) in Region 5 (statistical trend) and higher mean diffusivity (MD) in Regions 4 and 5 than HC, and patients with FES had higher MD in Region 3 (statistical trend) than HC. Both clinical groups performed worse on working memory and speed of processing tasks than HC, and patients with CS scored worse than HC on independent planning, and worse than FES and HC on dependent planning. Moreover, in patients with CS, MD in Region 3 was correlated with verbal working memory. Our results suggest that patients with FES and CS are characterized by impaired integrity of the middle and posterior CC, respectively. We confirmed that both clinical groups have cognitive impairments. Moreover, the integrity of the middle CC may influence planning in patients with CS.https://www.mdpi.com/2077-0383/10/14/3158corpus callosumworking memoryplanningspeed of processingfirst-episode schizophreniachronic schizophrenia |
| spellingShingle | Ernest Tyburski Piotr Podwalski Katarzyna Waszczuk Katarzyna Rek-Owodziń Monika Mak Piotr Plichta Maksymilian Bielecki Krzysztof Rudkowski Michał Szelepajło Jolanta Kucharska-Mazur Wojciech Andrusewicz Błażej Misiak Magdalena Kerestey Adrianna Bober Krzysztof Wietrzyński Anna Michalczyk Magdalena Więdłocha Piotr Marcinowicz Jerzy Samochowiec Leszek Sagan Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia Journal of Clinical Medicine corpus callosum working memory planning speed of processing first-episode schizophrenia chronic schizophrenia |
| title | Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia |
| title_full | Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia |
| title_fullStr | Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia |
| title_full_unstemmed | Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia |
| title_short | Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia |
| title_sort | relationship of corpus callosum integrity with working memory planning and speed of processing in patients with first episode and chronic schizophrenia |
| topic | corpus callosum working memory planning speed of processing first-episode schizophrenia chronic schizophrenia |
| url | https://www.mdpi.com/2077-0383/10/14/3158 |
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