Coherent Spontaneous Hemodynamics in the Human Brain
<italic>Goal:</italic> This work investigates the presence of cerebral hemodynamics (namely Oxy (O) and Deoxy (D) hemoglobin concentrations) that are coherent with spontaneous oscillations in Arterial Blood Pressure (ABP) in 78 healthy subjects during a driving simulation task. <itali...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2023-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10005252/ |
| _version_ | 1797346276026613760 |
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| author | Cristianne Fernandez Tapan Das Giles Blaney Zachary Haga Thomas McWilliams Julia Mertens Angelo Sassaroli Sergio Fantini |
| author_facet | Cristianne Fernandez Tapan Das Giles Blaney Zachary Haga Thomas McWilliams Julia Mertens Angelo Sassaroli Sergio Fantini |
| author_sort | Cristianne Fernandez |
| collection | DOAJ |
| description | <italic>Goal:</italic> This work investigates the presence of cerebral hemodynamics (namely Oxy (O) and Deoxy (D) hemoglobin concentrations) that are coherent with spontaneous oscillations in Arterial Blood Pressure (ABP) in 78 healthy subjects during a driving simulation task. <italic>Methods:</italic> Spatially resolved O and D were measured on the prefrontal cortex with multi-channel near-infrared spectroscopy (NIRS). Wavelet coherence and phasor analysis were performed between O and ABP, and between D and ABP to evaluate the amplitude ratio, phase difference, and duration of significant coherence. <italic>Results</italic>: In the low-frequency range, oscillations at 0.1 Hz featured significant coherence for the longest time fraction (∼10%–30%). At this frequency, the amplitude ratio and phase difference showed a greater variance across subjects than over cortical locations, and no significant difference between driving tasks and baseline. <italic>Conclusions</italic>: Measuring low-frequency cerebral hemodynamics that are coherent with systemic ABP holds promise for non-invasive assessment of cerebral perfusion and autoregulation at the cerebral microvascular level. |
| first_indexed | 2024-03-08T11:29:43Z |
| format | Article |
| id | doaj.art-16ef54343bc24c69a8d3bb38aa32957e |
| institution | Directory Open Access Journal |
| issn | 2644-1276 |
| language | English |
| last_indexed | 2024-03-08T11:29:43Z |
| publishDate | 2023-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj.art-16ef54343bc24c69a8d3bb38aa32957e2024-01-26T00:02:06ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762023-01-01410210810.1109/OJEMB.2023.323401210005252Coherent Spontaneous Hemodynamics in the Human BrainCristianne Fernandez0https://orcid.org/0000-0002-6446-8310Tapan Das1https://orcid.org/0000-0003-2712-8736Giles Blaney2https://orcid.org/0000-0003-3419-4547Zachary Haga3Thomas McWilliams4https://orcid.org/0000-0002-4183-420XJulia Mertens5Angelo Sassaroli6https://orcid.org/0000-0003-4233-7165Sergio Fantini7https://orcid.org/0000-0001-5116-525XDepartment of Biomedical Engineering, Tufts University, Medford, MA, USADepartment of Biomedical Engineering, Tufts University, Medford, MA, USADepartment of Biomedical Engineering, Tufts University, Medford, MA, USADepartment of Computer Science, Tufts University, Medford, MA, USADepartment of Psychology, Tufts University, Medford, MA, USADepartment of Psychology, Tufts University, Medford, MA, USADepartment of Biomedical Engineering, Tufts University, Medford, MA, USADepartment of Biomedical Engineering, Tufts University, Medford, MA, USA<italic>Goal:</italic> This work investigates the presence of cerebral hemodynamics (namely Oxy (O) and Deoxy (D) hemoglobin concentrations) that are coherent with spontaneous oscillations in Arterial Blood Pressure (ABP) in 78 healthy subjects during a driving simulation task. <italic>Methods:</italic> Spatially resolved O and D were measured on the prefrontal cortex with multi-channel near-infrared spectroscopy (NIRS). Wavelet coherence and phasor analysis were performed between O and ABP, and between D and ABP to evaluate the amplitude ratio, phase difference, and duration of significant coherence. <italic>Results</italic>: In the low-frequency range, oscillations at 0.1 Hz featured significant coherence for the longest time fraction (∼10%–30%). At this frequency, the amplitude ratio and phase difference showed a greater variance across subjects than over cortical locations, and no significant difference between driving tasks and baseline. <italic>Conclusions</italic>: Measuring low-frequency cerebral hemodynamics that are coherent with systemic ABP holds promise for non-invasive assessment of cerebral perfusion and autoregulation at the cerebral microvascular level.https://ieeexplore.ieee.org/document/10005252/Near infrared spectroscopyspontaneous oscillationstransfer function analysiscoherent hemodynamics |
| spellingShingle | Cristianne Fernandez Tapan Das Giles Blaney Zachary Haga Thomas McWilliams Julia Mertens Angelo Sassaroli Sergio Fantini Coherent Spontaneous Hemodynamics in the Human Brain IEEE Open Journal of Engineering in Medicine and Biology Near infrared spectroscopy spontaneous oscillations transfer function analysis coherent hemodynamics |
| title | Coherent Spontaneous Hemodynamics in the Human Brain |
| title_full | Coherent Spontaneous Hemodynamics in the Human Brain |
| title_fullStr | Coherent Spontaneous Hemodynamics in the Human Brain |
| title_full_unstemmed | Coherent Spontaneous Hemodynamics in the Human Brain |
| title_short | Coherent Spontaneous Hemodynamics in the Human Brain |
| title_sort | coherent spontaneous hemodynamics in the human brain |
| topic | Near infrared spectroscopy spontaneous oscillations transfer function analysis coherent hemodynamics |
| url | https://ieeexplore.ieee.org/document/10005252/ |
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