Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies
Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H<sub>2</sub>S) and the nitric oxide ra...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2673-7140/2/3/19 |
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| author | Celia María Curieses Andrés José Manuel Pérez de la Lastra Celia Andrés Juan Francisco J. Plou Eduardo Pérez-Lebeña |
| author_facet | Celia María Curieses Andrés José Manuel Pérez de la Lastra Celia Andrés Juan Francisco J. Plou Eduardo Pérez-Lebeña |
| author_sort | Celia María Curieses Andrés |
| collection | DOAJ |
| description | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H<sub>2</sub>S) and the nitric oxide radical (<sup>•</sup>NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H<sub>2</sub>O<sub>2</sub> in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H<sub>2</sub>O<sub>2</sub> in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses. |
| first_indexed | 2024-03-09T22:30:36Z |
| format | Article |
| id | doaj.art-16ef55a36dbc4316a5065b871e682995 |
| institution | Directory Open Access Journal |
| issn | 2673-7140 |
| language | English |
| last_indexed | 2024-03-09T22:30:36Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-16ef55a36dbc4316a5065b871e6829952023-11-23T18:58:02ZengMDPI AGStresses2673-71402022-07-012325627410.3390/stresses2030019Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various PathologiesCelia María Curieses Andrés0José Manuel Pérez de la Lastra1Celia Andrés Juan2Francisco J. Plou3Eduardo Pérez-Lebeña4Hospital Clínico Universitario of Valladolid, Avenida de Ramón y Cajal, 3, 47003 Valladolid, SpainInstitute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, SpainCinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Belén, 7, 47011 Valladolid, SpainInstitute of Catalysis and Petrochemistry, CSIC-Spanish Research Council, 28049 Madrid, SpainSistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, SpainHydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H<sub>2</sub>S) and the nitric oxide radical (<sup>•</sup>NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H<sub>2</sub>O<sub>2</sub> in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H<sub>2</sub>O<sub>2</sub> in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.https://www.mdpi.com/2673-7140/2/3/19hydrogen peroxide H<sub>2</sub>O<sub>2</sub>metabolic responseinduced pathologies |
| spellingShingle | Celia María Curieses Andrés José Manuel Pérez de la Lastra Celia Andrés Juan Francisco J. Plou Eduardo Pérez-Lebeña Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies Stresses hydrogen peroxide H<sub>2</sub>O<sub>2</sub> metabolic response induced pathologies |
| title | Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies |
| title_full | Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies |
| title_fullStr | Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies |
| title_full_unstemmed | Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies |
| title_short | Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies |
| title_sort | chemistry of hydrogen peroxide formation and elimination in mammalian cells and its role in various pathologies |
| topic | hydrogen peroxide H<sub>2</sub>O<sub>2</sub> metabolic response induced pathologies |
| url | https://www.mdpi.com/2673-7140/2/3/19 |
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