New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-12-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/12/4741 |
| _version_ | 1811186398702600192 |
|---|---|
| author | Bin Yang Shengrong Liao Xiuping Lin Junfeng Wang Juan Liu Xuefeng Zhou Xianwen Yang Yonghong Liu |
| author_facet | Bin Yang Shengrong Liao Xiuping Lin Junfeng Wang Juan Liu Xuefeng Zhou Xianwen Yang Yonghong Liu |
| author_sort | Bin Yang |
| collection | DOAJ |
| description | Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively. |
| first_indexed | 2024-04-11T13:45:14Z |
| format | Article |
| id | doaj.art-16f1e55517b74c499ec55be1f8807a15 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:45:14Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-16f1e55517b74c499ec55be1f8807a152022-12-22T04:21:07ZengMDPI AGMarine Drugs1660-33972013-12-0111124741475010.3390/md11124741md11124741New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.Bin Yang0Shengrong Liao1Xiuping Lin2Junfeng Wang3Juan Liu4Xuefeng Zhou5Xianwen Yang6Yonghong Liu7CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaFour new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.http://www.mdpi.com/1660-3397/11/12/4741soft coralSinularia sp.sesquiterpenessinularianinsNF-κB |
| spellingShingle | Bin Yang Shengrong Liao Xiuping Lin Junfeng Wang Juan Liu Xuefeng Zhou Xianwen Yang Yonghong Liu New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Marine Drugs soft coral Sinularia sp. sesquiterpenes sinularianins NF-κB |
| title | New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. |
| title_full | New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. |
| title_fullStr | New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. |
| title_full_unstemmed | New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. |
| title_short | New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. |
| title_sort | new sinularianin sesquiterpenes from soft coral sinularia sp |
| topic | soft coral Sinularia sp. sesquiterpenes sinularianins NF-κB |
| url | http://www.mdpi.com/1660-3397/11/12/4741 |
| work_keys_str_mv | AT binyang newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT shengrongliao newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT xiupinglin newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT junfengwang newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT juanliu newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT xuefengzhou newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT xianwenyang newsinularianinsesquiterpenesfromsoftcoralsinulariasp AT yonghongliu newsinularianinsesquiterpenesfromsoftcoralsinulariasp |