Population pharmacokinetics of tigecycline in critically ill patients

Population pharmacokinetics of tigecycline in critically ill patients

Objective: In critically ill patients, the change of pathophysiological status may affect the pharmacokinetic (PK) process of drugs. The purpose of this study was to develop a PK model for tigecycline in critically ill patients, identify the factors influencing the PK and optimiz dosing regimens.Met...

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Bibliographic Details
Main Authors: Xiangru Luo, Shiyi Wang, Dong Li, Jun Wen, Na Sun, Guangjun Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
critically ill patients
population pharmacokinetics
tigecycline
Monte Carlo simulation
dosage regimen
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1083464/full

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