Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis
BackgroundOrganophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of the association.ObjectiveThis study provides a systematic review and meta-analysis of the impacts of OP pesticides on semen quality a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1227836/full |
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| author | Moses A. Hamed Moses A. Hamed Moses A. Hamed Tunmise M. Akhigbe Tunmise M. Akhigbe Adetomiwa E. Adeogun Adetomiwa E. Adeogun Oluwatosin B. Adesoye Oluwatosin B. Adesoye Oluwatosin B. Adesoye Roland E. Akhigbe Roland E. Akhigbe |
| author_facet | Moses A. Hamed Moses A. Hamed Moses A. Hamed Tunmise M. Akhigbe Tunmise M. Akhigbe Adetomiwa E. Adeogun Adetomiwa E. Adeogun Oluwatosin B. Adesoye Oluwatosin B. Adesoye Oluwatosin B. Adesoye Roland E. Akhigbe Roland E. Akhigbe |
| author_sort | Moses A. Hamed |
| collection | DOAJ |
| description | BackgroundOrganophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of the association.ObjectiveThis study provides a systematic review and meta-analysis of the impacts of OP pesticides on semen quality and male reproductive hormones.MethodsThis study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. Strategic search was conducted using combined text words as search terms. The eligibility criteria were developed based on Population, Exposure, Comparator, Outcome, and Study designs (PECOS) framework. Relevant data were extracted, risk of bias was evaluated by The Office of Health Assessment and Translation (OHAT) tool, and certainty of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group guidelines. Quantitative meta-analysis was performed by using Review Manager.ResultsA total of 766 male subjects (349 exposed to OP pesticides and 417 unexposed controls) were included in the meta-analysis. There was no significant difference in the ejaculate volume, seminal fluid volume, sperm multiple anomaly index, sperm, and leukocytes levels of the OP-exposed subjects compared to the control. In addition, OP pesticides exposure did not significantly affect serum concentrations of FSH, LH, and testosterone in subjects who were exposed to OP pesticides compared to their unexposed counterparts. However, we found a significant reduction in the sperm count, sperm concentration, progressive sperm motility, total sperm motility, and normal sperm morphology of OP pesticides-exposed subjects compared to the unexposed subjects. However, after subtype and sensitivity analyses, exposure to OP pesticides did not reduce sperm count. Also, after sensitivity analysis, OP pesticides exposure did not alter progressive sperm motility.ConclusionThis study demonstrates that OP pesticides exposure reduced sperm count, concentration, total and progressive motility, and normal sperm morphology, possibly via a testosterone-independent mechanism. |
| first_indexed | 2024-03-11T15:31:48Z |
| format | Article |
| id | doaj.art-16f4aa29cac24bda90a280e882aee475 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T15:31:48Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-16f4aa29cac24bda90a280e882aee4752023-10-27T02:21:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12278361227836Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysisMoses A. Hamed0Moses A. Hamed1Moses A. Hamed2Tunmise M. Akhigbe3Tunmise M. Akhigbe4Adetomiwa E. Adeogun5Adetomiwa E. Adeogun6Oluwatosin B. Adesoye7Oluwatosin B. Adesoye8Oluwatosin B. Adesoye9Roland E. Akhigbe10Roland E. Akhigbe11Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Ekiti State, NigeriaThe Brainwill Laboratory, Osogbo, Osun State, NigeriaReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, NigeriaReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, NigeriaDepartment of Agronomy, Osun State Univeristy, Osogbo, NigeriaReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, NigeriaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NigeriaSickleLive Foundationo, Osogb, NigeriaSickleLive Foundation Research Laboratory, Osogbo, NigeriaState Specialist Hospital, Osogbo, Osun State, NigeriaReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, NigeriaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NigeriaBackgroundOrganophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of the association.ObjectiveThis study provides a systematic review and meta-analysis of the impacts of OP pesticides on semen quality and male reproductive hormones.MethodsThis study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. Strategic search was conducted using combined text words as search terms. The eligibility criteria were developed based on Population, Exposure, Comparator, Outcome, and Study designs (PECOS) framework. Relevant data were extracted, risk of bias was evaluated by The Office of Health Assessment and Translation (OHAT) tool, and certainty of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group guidelines. Quantitative meta-analysis was performed by using Review Manager.ResultsA total of 766 male subjects (349 exposed to OP pesticides and 417 unexposed controls) were included in the meta-analysis. There was no significant difference in the ejaculate volume, seminal fluid volume, sperm multiple anomaly index, sperm, and leukocytes levels of the OP-exposed subjects compared to the control. In addition, OP pesticides exposure did not significantly affect serum concentrations of FSH, LH, and testosterone in subjects who were exposed to OP pesticides compared to their unexposed counterparts. However, we found a significant reduction in the sperm count, sperm concentration, progressive sperm motility, total sperm motility, and normal sperm morphology of OP pesticides-exposed subjects compared to the unexposed subjects. However, after subtype and sensitivity analyses, exposure to OP pesticides did not reduce sperm count. Also, after sensitivity analysis, OP pesticides exposure did not alter progressive sperm motility.ConclusionThis study demonstrates that OP pesticides exposure reduced sperm count, concentration, total and progressive motility, and normal sperm morphology, possibly via a testosterone-independent mechanism.https://www.frontiersin.org/articles/10.3389/fendo.2023.1227836/fullendocrine disruptorsenvironmental toxicantshormone imbalancemale infertilityorganophosphatepesticides |
| spellingShingle | Moses A. Hamed Moses A. Hamed Moses A. Hamed Tunmise M. Akhigbe Tunmise M. Akhigbe Adetomiwa E. Adeogun Adetomiwa E. Adeogun Oluwatosin B. Adesoye Oluwatosin B. Adesoye Oluwatosin B. Adesoye Roland E. Akhigbe Roland E. Akhigbe Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis Frontiers in Endocrinology endocrine disruptors environmental toxicants hormone imbalance male infertility organophosphate pesticides |
| title | Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis |
| title_full | Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis |
| title_fullStr | Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis |
| title_full_unstemmed | Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis |
| title_short | Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis |
| title_sort | impact of organophosphate pesticides exposure on human semen parameters and testosterone a systematic review and meta analysis |
| topic | endocrine disruptors environmental toxicants hormone imbalance male infertility organophosphate pesticides |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1227836/full |
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