Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries
Mycobacterium tuberculosis (MTB) is the causative agent of TB. TB incidence is high in many low resource settings where limited health systems make it difficult for screening of co-morbid conditions. Susceptibility to TB is increased with coincident diabetes mellitus (DM) or prediabetes. DM leads to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405579422000481 |
| _version_ | 1811187565639761920 |
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| author | Uzair Abbas Kiran Iqbal Masood Aalia Khan Muhammad Irfan Nausheen Saifullah Bushra Jamil Zahra Hasan |
| author_facet | Uzair Abbas Kiran Iqbal Masood Aalia Khan Muhammad Irfan Nausheen Saifullah Bushra Jamil Zahra Hasan |
| author_sort | Uzair Abbas |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (MTB) is the causative agent of TB. TB incidence is high in many low resource settings where limited health systems make it difficult for screening of co-morbid conditions. Susceptibility to TB is increased with coincident diabetes mellitus (DM) or prediabetes. DM leads to chronic, subclinical inflammation in the host leading to compromised protective immunity against MTB, impacting TB treatment. This review focuses on the immunological impact of DM and prediabetes on TB infections, highlighting the importance of having effective diagnostic, treatment and management programs for early identification of hyperglycemia in TB patients to improve treatment outcomes. Further, it describes challenges in monitoring of TB and DM co-morbidity in a high-burden setting. |
| first_indexed | 2024-04-11T14:04:29Z |
| format | Article |
| id | doaj.art-16f4ba3cbb214c80853f7f2144d78504 |
| institution | Directory Open Access Journal |
| issn | 2405-5794 |
| language | English |
| last_indexed | 2024-04-11T14:04:29Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| spelling | doaj.art-16f4ba3cbb214c80853f7f2144d785042022-12-22T04:19:55ZengElsevierJournal of Clinical Tuberculosis and Other Mycobacterial Diseases2405-57942022-12-0129100343Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countriesUzair Abbas0Kiran Iqbal Masood1Aalia Khan2Muhammad Irfan3Nausheen Saifullah4Bushra Jamil5Zahra Hasan6Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, PakistanDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, PakistanDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, PakistanDepartment of Medicine, The Aga Khan University, Karachi, PakistanDepartment of Chest Diseases, Jinnah Post-graduate Medical Centre, Karachi, PakistanDepartment of Medicine, The Aga Khan University, Karachi, PakistanDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan; Corresponding author.Mycobacterium tuberculosis (MTB) is the causative agent of TB. TB incidence is high in many low resource settings where limited health systems make it difficult for screening of co-morbid conditions. Susceptibility to TB is increased with coincident diabetes mellitus (DM) or prediabetes. DM leads to chronic, subclinical inflammation in the host leading to compromised protective immunity against MTB, impacting TB treatment. This review focuses on the immunological impact of DM and prediabetes on TB infections, highlighting the importance of having effective diagnostic, treatment and management programs for early identification of hyperglycemia in TB patients to improve treatment outcomes. Further, it describes challenges in monitoring of TB and DM co-morbidity in a high-burden setting.http://www.sciencedirect.com/science/article/pii/S2405579422000481TuberculosisDiabetesPrediabetesImmunityTB management |
| spellingShingle | Uzair Abbas Kiran Iqbal Masood Aalia Khan Muhammad Irfan Nausheen Saifullah Bushra Jamil Zahra Hasan Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Tuberculosis Diabetes Prediabetes Immunity TB management |
| title | Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries |
| title_full | Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries |
| title_fullStr | Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries |
| title_full_unstemmed | Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries |
| title_short | Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries |
| title_sort | tuberculosis and diabetes mellitus relating immune impact of co morbidity with challenges in disease management in high burden countries |
| topic | Tuberculosis Diabetes Prediabetes Immunity TB management |
| url | http://www.sciencedirect.com/science/article/pii/S2405579422000481 |
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