Abscission checkpoint control: stuck in the middle with Aurora B
At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, t...
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| Format: | Article |
| Language: | English |
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The Royal Society
2012-01-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120095 |
| _version_ | 1818934897823186944 |
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| author | Mar Carmena |
| author_facet | Mar Carmena |
| author_sort | Mar Carmena |
| collection | DOAJ |
| description | At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission. |
| first_indexed | 2024-12-20T05:11:35Z |
| format | Article |
| id | doaj.art-16f52dfb346a463da4bd43399766915a |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-20T05:11:35Z |
| publishDate | 2012-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-16f52dfb346a463da4bd43399766915a2022-12-21T19:52:16ZengThe Royal SocietyOpen Biology2046-24412012-01-012710.1098/rsob.120095120095Abscission checkpoint control: stuck in the middle with Aurora BMar CarmenaAt the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120095aurora b kinasechromosomal passenger complexendosomal sorting complex required for transport-iiicytokinesisabscissioncheckpoint |
| spellingShingle | Mar Carmena Abscission checkpoint control: stuck in the middle with Aurora B Open Biology aurora b kinase chromosomal passenger complex endosomal sorting complex required for transport-iii cytokinesis abscission checkpoint |
| title | Abscission checkpoint control: stuck in the middle with Aurora B |
| title_full | Abscission checkpoint control: stuck in the middle with Aurora B |
| title_fullStr | Abscission checkpoint control: stuck in the middle with Aurora B |
| title_full_unstemmed | Abscission checkpoint control: stuck in the middle with Aurora B |
| title_short | Abscission checkpoint control: stuck in the middle with Aurora B |
| title_sort | abscission checkpoint control stuck in the middle with aurora b |
| topic | aurora b kinase chromosomal passenger complex endosomal sorting complex required for transport-iii cytokinesis abscission checkpoint |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120095 |
| work_keys_str_mv | AT marcarmena abscissioncheckpointcontrolstuckinthemiddlewithaurorab |