PDGF‐BB‐Dependent Neurogenesis Buffers Depressive‐Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus

PDGF‐BB‐Dependent Neurogenesis Buffers Depressive‐Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus

Abstract Hippocampal circuitry stimulation is sufficient to regulate adult hippocampal neurogenesis and ameliorate depressive‐like behavior, but its underlying mechanism remains unclear. Here, it is shown that inhibition of medial septum (MS)‐dentate gyrus (DG) circuit reverses the chronic social de...

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Bibliographic Details
Main Authors: Hou‐Hong Li, Yang Liu, Hong‐Sheng Chen, Ji Wang, Yu‐Ke Li, Yang Zhao, Rui Sun, Jin‐Gang He, Fang Wang, Jian‐Guo Chen
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
depressive‐like behaviors
MS‐DG pathway
neurogenesis
PDGF‐BB
Online Access:https://doi.org/10.1002/advs.202301110

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