Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin

Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin

Linagliptin, a xanthine derivative, is a highly potent, selective, long-acting and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. During the process development of linagliptin, five new process-related impurities were detected by high performance liquid chromatography (HPL...

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Detalles Bibliográficos
Main Authors: Yiwen Huang, Xiaoqing He, Taizhi Wu, Fuli Zhang
Formato: Artigo
Idioma:English
Publicado: MDPI AG 2016-08-01
Series:Molecules
Subjects:
linagliptin
type 2 diabetes
impurities
synthesis
characterization
Acceso en liña:http://www.mdpi.com/1420-3049/21/8/1041

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