Controversies Surrounding Clostridium difficile Infection in Infants and Young Children
Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Children |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9067/1/1/40 |
| _version_ | 1818666942456659968 |
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| author | Maribeth R. Nicholson Isaac P. Thomsen Kathryn M. Edwards |
| author_facet | Maribeth R. Nicholson Isaac P. Thomsen Kathryn M. Edwards |
| author_sort | Maribeth R. Nicholson |
| collection | DOAJ |
| description | Clostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin internalization. Determining which children who test positive for C. difficile warrant treatment is exceedingly difficult, especially in the setting of increased rates of detection and the rising risk of disease in children lacking classic risk factors for C. difficile. |
| first_indexed | 2024-12-17T06:12:33Z |
| format | Article |
| id | doaj.art-16f56dbae0ec40e8806758ea6983776c |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-12-17T06:12:33Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-16f56dbae0ec40e8806758ea6983776c2022-12-21T22:00:35ZengMDPI AGChildren2227-90672014-06-0111404710.3390/children1010040children1010040Controversies Surrounding Clostridium difficile Infection in Infants and Young ChildrenMaribeth R. Nicholson0Isaac P. Thomsen1Kathryn M. Edwards2Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, 2200 Children's Way, Nashville TN 37232, USADivision of Pediatric Infectious Disease, Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine, 2200 Children's Way, Nashville, TN 37232, USADivision of Pediatric Infectious Disease, Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine, 2200 Children's Way, Nashville, TN 37232, USAClostridium difficile is a frequent cause of antibiotic-associated diarrhea in adults and older children. However, as many as 80% of infants can be asymptomatically colonized. The reasons for this have not been well established but are believed to be due to differences in toxin receptors or toxin internalization. Determining which children who test positive for C. difficile warrant treatment is exceedingly difficult, especially in the setting of increased rates of detection and the rising risk of disease in children lacking classic risk factors for C. difficile.http://www.mdpi.com/2227-9067/1/1/40Clostridium difficilecolonizationneonatesdiarrhea |
| spellingShingle | Maribeth R. Nicholson Isaac P. Thomsen Kathryn M. Edwards Controversies Surrounding Clostridium difficile Infection in Infants and Young Children Children Clostridium difficile colonization neonates diarrhea |
| title | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
| title_full | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
| title_fullStr | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
| title_full_unstemmed | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
| title_short | Controversies Surrounding Clostridium difficile Infection in Infants and Young Children |
| title_sort | controversies surrounding clostridium difficile infection in infants and young children |
| topic | Clostridium difficile colonization neonates diarrhea |
| url | http://www.mdpi.com/2227-9067/1/1/40 |
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