Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/8/2636 |
| _version_ | 1797558282454302720 |
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| author | Jessica Le Blanc François Mullier Caroline Vayne Marie Lordkipanidzé |
| author_facet | Jessica Le Blanc François Mullier Caroline Vayne Marie Lordkipanidzé |
| author_sort | Jessica Le Blanc |
| collection | DOAJ |
| description | Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications. |
| first_indexed | 2024-03-10T17:28:04Z |
| format | Article |
| id | doaj.art-16f6ce6d48d34322ace77eaca87f3a25 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T17:28:04Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-16f6ce6d48d34322ace77eaca87f3a252023-11-20T10:05:42ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0198263610.3390/jcm9082636Advances in Platelet Function Testing—Light Transmission Aggregometry and BeyondJessica Le Blanc0François Mullier1Caroline Vayne2Marie Lordkipanidzé3Montreal Heart Institute Research Center, Montréal, QC H1T 1C8, CanadaUniversité catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Hematology Laboratory, 5530 Yvoir, BelgiumDepartment of Hemostasis, University Hospital of Tours, 37044 Tours, FranceMontreal Heart Institute Research Center, Montréal, QC H1T 1C8, CanadaPlatelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications.https://www.mdpi.com/2077-0383/9/8/2636plateletsplatelet functional testslight transmission aggregometrystandardization |
| spellingShingle | Jessica Le Blanc François Mullier Caroline Vayne Marie Lordkipanidzé Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond Journal of Clinical Medicine platelets platelet functional tests light transmission aggregometry standardization |
| title | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
| title_full | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
| title_fullStr | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
| title_full_unstemmed | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
| title_short | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
| title_sort | advances in platelet function testing light transmission aggregometry and beyond |
| topic | platelets platelet functional tests light transmission aggregometry standardization |
| url | https://www.mdpi.com/2077-0383/9/8/2636 |
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