A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding
Introduction : There are insufficient data regarding the changes in adipokine levels after laparoscopic adjustable gastric banding (LAGB) in diabetic and non-diabetic patients and their effects on insulin resistance and type 2 diabetes remission. Aim : To assess leptin, adiponectin, and insulin re...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-04-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
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| Online Access: | https://www.termedia.pl/A-prospective-4-year-study-of-insulin-resistance-and-adipokines-in-morbidly-obese-diabetic-and-non-diabetic-patients-after-gastric-banding,42,29816,1,1.html |
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| author | Vaidotas Urbanavicius Zygimantas Juodeikis Vilma Dzenkeviciute Aiste Galkine Zaneta Petrulioniene Virginijus Sapoka Vilma Brimiene Dalius Vitkus Gintautas Brimas |
| author_facet | Vaidotas Urbanavicius Zygimantas Juodeikis Vilma Dzenkeviciute Aiste Galkine Zaneta Petrulioniene Virginijus Sapoka Vilma Brimiene Dalius Vitkus Gintautas Brimas |
| author_sort | Vaidotas Urbanavicius |
| collection | DOAJ |
| description | Introduction : There are insufficient data regarding the changes in adipokine levels after laparoscopic adjustable gastric banding (LAGB) in diabetic and non-diabetic patients and their effects on insulin resistance and type 2 diabetes remission.
Aim : To assess leptin, adiponectin, and insulin resistance changes after LAGB in diabetic and non-diabetic morbidly obese patients.
Material and methods : One hundred and three patients (37 with and 66 without type 2 diabetes) underwent LAGB from January 2009 to January 2010. Glycated hemoglobin, insulin, adipokine levels and insulin resistance were evaluated preoperatively, and 1 and 4 years after LAGB.
Results : The mean patient age was 45.9 ±11.7 years and mean preoperative body mass index was 47.5 ±7.3 kg/m2. A total of 80 of 103 patients (77.6%) completed the 4-year follow-up. After 4 years the mean excess weight loss was 38.8% and 39.5% in diabetic and non-diabetic patients respectively. Leptin levels decreased significantly in both groups at 1 year, but after 4 years this was noted only in non-diabetic patients. After 1 year adiponectin levels increased significantly only in non-diabetic patients (p = 0.003) and remained almost the same at 4 years. A significant decrease in insulin resistance was noted in both groups 1 year after LAGB and diabetes remission was observed in 23 (62.1%) patients. There was a negative correlation between preoperative insulin resistance and adiponectin levels throughout the follow-up period. Leptin levels positively correlated with BMI throughout the study period (baseline r = 0.45; p < 0.001; after 1 year r = 0.71; p < 0.001; after 4 years r = 0.68; p < 0.001). There was no significant correlation between leptin and adiponectin concentrations preoperatively or after 1 year; however, at 4 years it was significant (r = 0.27; p < 0.02).
Conclusions : The most significant metabolic changes occurred within 1 year after LAGB. The 4-year follow-up revealed stabilization in metabolic indices rather than significant improvement. |
| first_indexed | 2024-12-10T14:36:35Z |
| format | Article |
| id | doaj.art-16f8055ab04f402197e3a270c79b8166 |
| institution | Directory Open Access Journal |
| issn | 1895-4588 2299-0054 |
| language | English |
| last_indexed | 2024-12-10T14:36:35Z |
| publishDate | 2017-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Videosurgery and Other Miniinvasive Techniques |
| spelling | doaj.art-16f8055ab04f402197e3a270c79b81662022-12-22T01:44:48ZengTermedia Publishing HouseVideosurgery and Other Miniinvasive Techniques1895-45882299-00542017-04-0112214715310.5114/wiitm.2017.6720729816A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric bandingVaidotas UrbanaviciusZygimantas JuodeikisVilma DzenkeviciuteAiste GalkineZaneta PetrulionieneVirginijus SapokaVilma BrimieneDalius VitkusGintautas BrimasIntroduction : There are insufficient data regarding the changes in adipokine levels after laparoscopic adjustable gastric banding (LAGB) in diabetic and non-diabetic patients and their effects on insulin resistance and type 2 diabetes remission. Aim : To assess leptin, adiponectin, and insulin resistance changes after LAGB in diabetic and non-diabetic morbidly obese patients. Material and methods : One hundred and three patients (37 with and 66 without type 2 diabetes) underwent LAGB from January 2009 to January 2010. Glycated hemoglobin, insulin, adipokine levels and insulin resistance were evaluated preoperatively, and 1 and 4 years after LAGB. Results : The mean patient age was 45.9 ±11.7 years and mean preoperative body mass index was 47.5 ±7.3 kg/m2. A total of 80 of 103 patients (77.6%) completed the 4-year follow-up. After 4 years the mean excess weight loss was 38.8% and 39.5% in diabetic and non-diabetic patients respectively. Leptin levels decreased significantly in both groups at 1 year, but after 4 years this was noted only in non-diabetic patients. After 1 year adiponectin levels increased significantly only in non-diabetic patients (p = 0.003) and remained almost the same at 4 years. A significant decrease in insulin resistance was noted in both groups 1 year after LAGB and diabetes remission was observed in 23 (62.1%) patients. There was a negative correlation between preoperative insulin resistance and adiponectin levels throughout the follow-up period. Leptin levels positively correlated with BMI throughout the study period (baseline r = 0.45; p < 0.001; after 1 year r = 0.71; p < 0.001; after 4 years r = 0.68; p < 0.001). There was no significant correlation between leptin and adiponectin concentrations preoperatively or after 1 year; however, at 4 years it was significant (r = 0.27; p < 0.02). Conclusions : The most significant metabolic changes occurred within 1 year after LAGB. The 4-year follow-up revealed stabilization in metabolic indices rather than significant improvement.https://www.termedia.pl/A-prospective-4-year-study-of-insulin-resistance-and-adipokines-in-morbidly-obese-diabetic-and-non-diabetic-patients-after-gastric-banding,42,29816,1,1.html<i>laparoscopic adjustable gastric banding type 2 diabetes adiponectin leptin insulin resistance</i> |
| spellingShingle | Vaidotas Urbanavicius Zygimantas Juodeikis Vilma Dzenkeviciute Aiste Galkine Zaneta Petrulioniene Virginijus Sapoka Vilma Brimiene Dalius Vitkus Gintautas Brimas A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding Videosurgery and Other Miniinvasive Techniques <i>laparoscopic adjustable gastric banding type 2 diabetes adiponectin leptin insulin resistance</i> |
| title | A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding |
| title_full | A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding |
| title_fullStr | A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding |
| title_full_unstemmed | A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding |
| title_short | A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding |
| title_sort | prospective 4 year study of insulin resistance and adipokines in morbidly obese diabetic and non diabetic patients after gastric banding |
| topic | <i>laparoscopic adjustable gastric banding type 2 diabetes adiponectin leptin insulin resistance</i> |
| url | https://www.termedia.pl/A-prospective-4-year-study-of-insulin-resistance-and-adipokines-in-morbidly-obese-diabetic-and-non-diabetic-patients-after-gastric-banding,42,29816,1,1.html |
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