Efficacy of trabectedin in metastatic solitary fibrous tumor
Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-07-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/2754 |
| _version_ | 1818477223707934720 |
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| author | Xavier Pivot Laura Mansi Stephanie Servagi-Vernat Delphine Delroeux Julien Pauchot Lionel Aherfi Nicolas Isambert Christine Fagnoni-Legat Elsa Kalbacher Antoine Thiery-Vuillemin Loic Chaigneau |
| author_facet | Xavier Pivot Laura Mansi Stephanie Servagi-Vernat Delphine Delroeux Julien Pauchot Lionel Aherfi Nicolas Isambert Christine Fagnoni-Legat Elsa Kalbacher Antoine Thiery-Vuillemin Loic Chaigneau |
| author_sort | Xavier Pivot |
| collection | DOAJ |
| description | Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine andor ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option. |
| first_indexed | 2024-12-10T09:35:25Z |
| format | Article |
| id | doaj.art-16f839d13af14e579af2fd985a946f18 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-10T09:35:25Z |
| publishDate | 2011-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-16f839d13af14e579af2fd985a946f182022-12-22T01:54:12ZengSAGE PublishingRare Tumors2036-36052036-36132011-07-0133e29e2910.4081/rt.2011.e29Efficacy of trabectedin in metastatic solitary fibrous tumorXavier PivotLaura MansiStephanie Servagi-VernatDelphine DelroeuxJulien PauchotLionel AherfiNicolas IsambertChristine Fagnoni-LegatElsa KalbacherAntoine Thiery-VuilleminLoic ChaigneauSolitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine andor ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.http://www.pagepress.org/journals/index.php/rt/article/view/2754metastatic solitary fibrous tumor, trabectedin |
| spellingShingle | Xavier Pivot Laura Mansi Stephanie Servagi-Vernat Delphine Delroeux Julien Pauchot Lionel Aherfi Nicolas Isambert Christine Fagnoni-Legat Elsa Kalbacher Antoine Thiery-Vuillemin Loic Chaigneau Efficacy of trabectedin in metastatic solitary fibrous tumor Rare Tumors metastatic solitary fibrous tumor, trabectedin |
| title | Efficacy of trabectedin in metastatic solitary fibrous tumor |
| title_full | Efficacy of trabectedin in metastatic solitary fibrous tumor |
| title_fullStr | Efficacy of trabectedin in metastatic solitary fibrous tumor |
| title_full_unstemmed | Efficacy of trabectedin in metastatic solitary fibrous tumor |
| title_short | Efficacy of trabectedin in metastatic solitary fibrous tumor |
| title_sort | efficacy of trabectedin in metastatic solitary fibrous tumor |
| topic | metastatic solitary fibrous tumor, trabectedin |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/2754 |
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