Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease

Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease

The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ)...

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Bibliographic Details
Main Author:	Michael S. Wolfe
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Molecules
Subjects:	protease amyloid Alzheimer’s disease inhibitors modulators
Online Access:	https://www.mdpi.com/1420-3049/26/2/388

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