Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods
Introduction: Bronchiolitis Obliterans (BO) is one of the most important pulmonary complications of Hematopoietic Stem Cell Transplantation (HSCT). We decided to evaluate the prevalence and risk factors of BO in HSCT patients in the Shariati Hospital Oncology Research Center. Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-03-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/235 |
| _version_ | 1797722316624363520 |
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| author | Keyvan Gohari Moghadam Bahareh Marghoob Kamran Alimoghaddam Shapour Shirani Ardeshir Ghavamzadeh |
| author_facet | Keyvan Gohari Moghadam Bahareh Marghoob Kamran Alimoghaddam Shapour Shirani Ardeshir Ghavamzadeh |
| author_sort | Keyvan Gohari Moghadam |
| collection | DOAJ |
| description | Introduction: Bronchiolitis Obliterans (BO) is one of the most important pulmonary complications of Hematopoietic Stem Cell Transplantation (HSCT). We decided to evaluate the prevalence and risk factors of BO in HSCT patients in the Shariati Hospital Oncology Research Center.
Materials and Methods: Forty two patients, who had had HSCT for at least 6 months ago, completed the study. The diagnosis of BO was confirmed either by spirometry or inspiratory and expiratory views of HRCT with a FEV1/FVC lower than 75% or more than a 10% drop of FEV1/FVC from a baseline value and mosaic or air trapping on HRCT, respectively.
Results: Nineteen out of forty two patients were BO, with a prevalence of 45.2%; seventeen cases by HRCT and eleven by spirometry criteria. Identified risk factors for BO were acute and chronic GVHD, age 21-40 yrs. Female donor to male recipient and unmatched genders. There was a strong negative predictve value of symptoms under age 20.
Conclusion: Young patients under 20, without respiratory symptoms, need no further evaluation. Acute and chronic GVHD are again the main risk factors regarding female donors to male recipients within the age group of 21-40. |
| first_indexed | 2024-03-12T09:45:49Z |
| format | Article |
| id | doaj.art-16f91ba84de742e8becab138af0a8853 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T09:45:49Z |
| publishDate | 2010-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-16f91ba84de742e8becab138af0a88532023-09-02T12:52:39ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072010-03-0141Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic MethodsKeyvan Gohari Moghadam0Bahareh Marghoob1Kamran Alimoghaddam2Shapour Shirani3Ardeshir Ghavamzadeh4Pulmonoary Medicine Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranRadiology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranIntroduction: Bronchiolitis Obliterans (BO) is one of the most important pulmonary complications of Hematopoietic Stem Cell Transplantation (HSCT). We decided to evaluate the prevalence and risk factors of BO in HSCT patients in the Shariati Hospital Oncology Research Center. Materials and Methods: Forty two patients, who had had HSCT for at least 6 months ago, completed the study. The diagnosis of BO was confirmed either by spirometry or inspiratory and expiratory views of HRCT with a FEV1/FVC lower than 75% or more than a 10% drop of FEV1/FVC from a baseline value and mosaic or air trapping on HRCT, respectively. Results: Nineteen out of forty two patients were BO, with a prevalence of 45.2%; seventeen cases by HRCT and eleven by spirometry criteria. Identified risk factors for BO were acute and chronic GVHD, age 21-40 yrs. Female donor to male recipient and unmatched genders. There was a strong negative predictve value of symptoms under age 20. Conclusion: Young patients under 20, without respiratory symptoms, need no further evaluation. Acute and chronic GVHD are again the main risk factors regarding female donors to male recipients within the age group of 21-40.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/235Hematopoetic Stem Cell TransplantationBronchiolitis OblitetransPulmonary Complications |
| spellingShingle | Keyvan Gohari Moghadam Bahareh Marghoob Kamran Alimoghaddam Shapour Shirani Ardeshir Ghavamzadeh Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods International Journal of Hematology-Oncology and Stem Cell Research Hematopoetic Stem Cell Transplantation Bronchiolitis Oblitetrans Pulmonary Complications |
| title | Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods |
| title_full | Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods |
| title_fullStr | Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods |
| title_full_unstemmed | Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods |
| title_short | Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation: Risk Factors and Diagnostic Methods |
| title_sort | bronchiolitis obliterans following hematopoietic stem cell transplantation risk factors and diagnostic methods |
| topic | Hematopoetic Stem Cell Transplantation Bronchiolitis Oblitetrans Pulmonary Complications |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/235 |
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