Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study
Abstract Background Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of CVD are scarce. This study aimed to assess the interaction of dyslipidemia and high-sensitivity C-reactive protein (h...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01836-w |
| _version_ | 1797556762871595008 |
|---|---|
| author | Solim Essomandan Clémence Bafei Xianghai Zhao Changying Chen Junxiang Sun Qian Zhuang Xiangfeng Lu Yanchun Chen Xincheng Gu Fangyuan Liu Jialing Mu Lai Wei Pengfei Wei Yunjie Yin Hankun Xie Song Yang Chong Shen |
| author_facet | Solim Essomandan Clémence Bafei Xianghai Zhao Changying Chen Junxiang Sun Qian Zhuang Xiangfeng Lu Yanchun Chen Xincheng Gu Fangyuan Liu Jialing Mu Lai Wei Pengfei Wei Yunjie Yin Hankun Xie Song Yang Chong Shen |
| author_sort | Solim Essomandan Clémence Bafei |
| collection | DOAJ |
| description | Abstract Background Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of CVD are scarce. This study aimed to assess the interaction of dyslipidemia and high-sensitivity C-reactive protein (hs-CRP) on CVD. Methods This prospective cohort enrolled 4,128 adults at baseline in 2009 and followed them up until May 2022 for collecting CVD events. Cox-proportional hazard regression analysis estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) of the associations of increased hs-CRP (≥ 1 mg/L) and dyslipidemia with CVD. The additive interactions were explored using the relative excess risk of interaction (RERI) and the multiplicative interactions were assessed with HRs (95% CI) while the multiplicative interactions were assessed by the HRs (95% CI) of interaction terms. Results The HRs of the association between increased hs-CRP and CVD were 1.42 (95% CI: 1.14–1.79) and 1.17 (95% CI: 0.89–1.53) among subjects with normal lipid levels and subjects with dyslipidemia, respectively. Stratified analyses by hs-CRP levels showed that among participants with normal hs-CRP (< 1 mg/L), TC ≥ 240 mg/dL, LDL-C ≥ 160 mg/dL, non-HDL-C ≥ 190 mg/dL, ApoB < 0.7 g/L, and LDL/HDL-C ≥ 2.02 were associated with CVD [HRs (95%CIs): 1.75 (1.21–2.54), 2.16 (1.37–3.41), 1.95 (1.29–2.97), 1.37 (1.01–1.67), and 1.30 (1.00-1.69), all P < 0.05, respectively]. While in the population with increased hs-CRP, only ApoAI > 2.10 g/L had a significant association with CVD [HR (95% CI): 1.69 (1.14–2.51)]. Interaction analyses showed that increased hs-CRP had multiplicative and additive interactions with LDL-C ≥ 160 mg/dL and non-HDL-C ≥ 190 mg/dL on the risk of CVD [HRs (95%CIs): 0.309 (0.153–0.621), and 0.505 (0.295–0.866); RERIs (95%CIs): -1.704 (-3.430-0.021 and − 0.694 (-1.476-0.089), respectively, all P < 0.05]. Conclusion Overall our findings indicate negative interactions between abnormal blood lipid levels and hs-CRP on the risk of CVD. Further large-scale cohort studies with trajectories measurement of lipids and hs-CRP might verify our results as well explore the biological mechanism behind that interaction. |
| first_indexed | 2024-03-10T17:07:30Z |
| format | Article |
| id | doaj.art-16f98d20628d46629a81ba2763165daa |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-10T17:07:30Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-16f98d20628d46629a81ba2763165daa2023-11-20T10:45:37ZengBMCLipids in Health and Disease1476-511X2023-07-0122111110.1186/s12944-023-01836-wInteractive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort studySolim Essomandan Clémence Bafei0Xianghai Zhao1Changying Chen2Junxiang Sun3Qian Zhuang4Xiangfeng Lu5Yanchun Chen6Xincheng Gu7Fangyuan Liu8Jialing Mu9Lai Wei10Pengfei Wei11Yunjie Yin12Hankun Xie13Song Yang14Chong Shen15Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityDepartment of Cardiology, Affiliated Yixing People’s Hospital of Jiangsu University, People’s Hospital of Yixing CityDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical UniversityAbstract Background Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of CVD are scarce. This study aimed to assess the interaction of dyslipidemia and high-sensitivity C-reactive protein (hs-CRP) on CVD. Methods This prospective cohort enrolled 4,128 adults at baseline in 2009 and followed them up until May 2022 for collecting CVD events. Cox-proportional hazard regression analysis estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) of the associations of increased hs-CRP (≥ 1 mg/L) and dyslipidemia with CVD. The additive interactions were explored using the relative excess risk of interaction (RERI) and the multiplicative interactions were assessed with HRs (95% CI) while the multiplicative interactions were assessed by the HRs (95% CI) of interaction terms. Results The HRs of the association between increased hs-CRP and CVD were 1.42 (95% CI: 1.14–1.79) and 1.17 (95% CI: 0.89–1.53) among subjects with normal lipid levels and subjects with dyslipidemia, respectively. Stratified analyses by hs-CRP levels showed that among participants with normal hs-CRP (< 1 mg/L), TC ≥ 240 mg/dL, LDL-C ≥ 160 mg/dL, non-HDL-C ≥ 190 mg/dL, ApoB < 0.7 g/L, and LDL/HDL-C ≥ 2.02 were associated with CVD [HRs (95%CIs): 1.75 (1.21–2.54), 2.16 (1.37–3.41), 1.95 (1.29–2.97), 1.37 (1.01–1.67), and 1.30 (1.00-1.69), all P < 0.05, respectively]. While in the population with increased hs-CRP, only ApoAI > 2.10 g/L had a significant association with CVD [HR (95% CI): 1.69 (1.14–2.51)]. Interaction analyses showed that increased hs-CRP had multiplicative and additive interactions with LDL-C ≥ 160 mg/dL and non-HDL-C ≥ 190 mg/dL on the risk of CVD [HRs (95%CIs): 0.309 (0.153–0.621), and 0.505 (0.295–0.866); RERIs (95%CIs): -1.704 (-3.430-0.021 and − 0.694 (-1.476-0.089), respectively, all P < 0.05]. Conclusion Overall our findings indicate negative interactions between abnormal blood lipid levels and hs-CRP on the risk of CVD. Further large-scale cohort studies with trajectories measurement of lipids and hs-CRP might verify our results as well explore the biological mechanism behind that interaction.https://doi.org/10.1186/s12944-023-01836-whs-CRPDyslipidemiaCardiovascular diseases riskInteractive effect |
| spellingShingle | Solim Essomandan Clémence Bafei Xianghai Zhao Changying Chen Junxiang Sun Qian Zhuang Xiangfeng Lu Yanchun Chen Xincheng Gu Fangyuan Liu Jialing Mu Lai Wei Pengfei Wei Yunjie Yin Hankun Xie Song Yang Chong Shen Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study Lipids in Health and Disease hs-CRP Dyslipidemia Cardiovascular diseases risk Interactive effect |
| title | Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study |
| title_full | Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study |
| title_fullStr | Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study |
| title_full_unstemmed | Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study |
| title_short | Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study |
| title_sort | interactive effect of increased high sensitive c reactive protein and dyslipidemia on cardiovascular diseases a 12 year prospective cohort study |
| topic | hs-CRP Dyslipidemia Cardiovascular diseases risk Interactive effect |
| url | https://doi.org/10.1186/s12944-023-01836-w |
| work_keys_str_mv | AT solimessomandanclemencebafei interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT xianghaizhao interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT changyingchen interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT junxiangsun interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT qianzhuang interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT xiangfenglu interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT yanchunchen interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT xinchenggu interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT fangyuanliu interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT jialingmu interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT laiwei interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT pengfeiwei interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT yunjieyin interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT hankunxie interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT songyang interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy AT chongshen interactiveeffectofincreasedhighsensitivecreactiveproteinanddyslipidemiaoncardiovasculardiseasesa12yearprospectivecohortstudy |