The Genomic Organisation of the TRA/TRD Locus Validates the Peculiar Characteristics of Dromedary δ-Chain Expression

The Genomic Organisation of the TRA/TRD Locus Validates the Peculiar Characteristics of Dromedary δ-Chain Expression

The role of γδ T cells in vertebrate immunity is still an unsolved puzzle. Species such as humans and mice display a low percentage of these T lymphocytes (i.e., “γδ low species”) with a restricted diversity of γδ T cell receptors (TR). Conversely, artiodactyl species (i.e., “γδ high species”) accou...

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Bibliographic Details
Main Authors: Serafina Massari, Giovanna Linguiti, Francesco Giannico, Pietro D’Addabbo, Salvatrice Ciccarese, Rachele Antonacci
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
γδ T cell
T cell receptor
TRA/TRD locus
variable
diversity
joining and constant genes
Online Access:https://www.mdpi.com/2073-4425/12/4/544

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