The mechanism of linear ubiquitination in regulating cell death and correlative diseases
Abstract Linear ubiquitination is a specific post-translational modification in which ubiquitin is linked through M1 residue to form multiple types of polyubiquitin chains on substrates in order to regulate cellular processes. LUBAC comprised by HOIP, HOIL-1L, and SHARPIN as a sole E3 ligase catalyz...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-10-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-06183-3 |
| _version_ | 1797659757316669440 |
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| author | Liyuan Gao Wei Zhang Xiao hui Shi Xiaoyan Chang Yi Han Chundi Liu Zhitao Jiang Xiang Yang |
| author_facet | Liyuan Gao Wei Zhang Xiao hui Shi Xiaoyan Chang Yi Han Chundi Liu Zhitao Jiang Xiang Yang |
| author_sort | Liyuan Gao |
| collection | DOAJ |
| description | Abstract Linear ubiquitination is a specific post-translational modification in which ubiquitin is linked through M1 residue to form multiple types of polyubiquitin chains on substrates in order to regulate cellular processes. LUBAC comprised by HOIP, HOIL-1L, and SHARPIN as a sole E3 ligase catalyzes the generation of linear ubiquitin chains, and it is simultaneously adjusted by deubiquitinases such as OTULIN and CYLD. Several studies have shown that gene mutation of linear ubiquitination in mice accompanied by different modalities of cell death would develop relative diseases. Cell death is a fundamental physiological process and responsible for embryonic development, organ maintenance, and immunity response. Therefore, it is worth speculating that linear ubiquitin mediated signaling pathway would participate in different diseases. The relative literature search was done from core collection of electronic databases such as Web of Science, PubMed, and Google Scholar using keywords about main regulators of linear ubiquitination pathway. Here, we summarize the regulatory mechanism of linear ubiquitination on cellular signaling pathway in cells with apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. Intervening generation of linear ubiquitin chains in relative signaling pathway to regulate cell death might provide novel therapeutic insights for various human diseases. |
| first_indexed | 2024-03-11T18:20:47Z |
| format | Article |
| id | doaj.art-16fb40b176b04f1289f78874593cdb87 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-11T18:20:47Z |
| publishDate | 2023-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-16fb40b176b04f1289f78874593cdb872023-10-15T11:30:15ZengNature Publishing GroupCell Death and Disease2041-48892023-10-01141011310.1038/s41419-023-06183-3The mechanism of linear ubiquitination in regulating cell death and correlative diseasesLiyuan Gao0Wei Zhang1Xiao hui Shi2Xiaoyan Chang3Yi Han4Chundi Liu5Zhitao Jiang6Xiang Yang7Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineZhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineAbstract Linear ubiquitination is a specific post-translational modification in which ubiquitin is linked through M1 residue to form multiple types of polyubiquitin chains on substrates in order to regulate cellular processes. LUBAC comprised by HOIP, HOIL-1L, and SHARPIN as a sole E3 ligase catalyzes the generation of linear ubiquitin chains, and it is simultaneously adjusted by deubiquitinases such as OTULIN and CYLD. Several studies have shown that gene mutation of linear ubiquitination in mice accompanied by different modalities of cell death would develop relative diseases. Cell death is a fundamental physiological process and responsible for embryonic development, organ maintenance, and immunity response. Therefore, it is worth speculating that linear ubiquitin mediated signaling pathway would participate in different diseases. The relative literature search was done from core collection of electronic databases such as Web of Science, PubMed, and Google Scholar using keywords about main regulators of linear ubiquitination pathway. Here, we summarize the regulatory mechanism of linear ubiquitination on cellular signaling pathway in cells with apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. Intervening generation of linear ubiquitin chains in relative signaling pathway to regulate cell death might provide novel therapeutic insights for various human diseases.https://doi.org/10.1038/s41419-023-06183-3 |
| spellingShingle | Liyuan Gao Wei Zhang Xiao hui Shi Xiaoyan Chang Yi Han Chundi Liu Zhitao Jiang Xiang Yang The mechanism of linear ubiquitination in regulating cell death and correlative diseases Cell Death and Disease |
| title | The mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| title_full | The mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| title_fullStr | The mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| title_full_unstemmed | The mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| title_short | The mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| title_sort | mechanism of linear ubiquitination in regulating cell death and correlative diseases |
| url | https://doi.org/10.1038/s41419-023-06183-3 |
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