Biocompatible fibers from fungal and shrimp chitosans for suture application
Purified fungal chitosan and crustacean chitosan were wet spun by using adipic and lactic acids as solvent. The lowest viscosity at which fiber formation was possible was 0.5 Pa·s; below this value, aggregates from low molecular weight fungal chitosan (32 kDa) formed, which could not be collected an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590262822000442 |
| _version_ | 1811178104258822144 |
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| author | Natacha Perrin Ghasem Mohammadkhani Farshad Homayouni Moghadam Cédric Delattre Akram Zamani |
| author_facet | Natacha Perrin Ghasem Mohammadkhani Farshad Homayouni Moghadam Cédric Delattre Akram Zamani |
| author_sort | Natacha Perrin |
| collection | DOAJ |
| description | Purified fungal chitosan and crustacean chitosan were wet spun by using adipic and lactic acids as solvent. The lowest viscosity at which fiber formation was possible was 0.5 Pa·s; below this value, aggregates from low molecular weight fungal chitosan (32 kDa) formed, which could not be collected and dried. Fiber formation was achieved with high molecular weight fungal (400 kDa) and shrimp (406.7 kDa) chitosans as well as low molecular weight shrimp chitosan (50–190 kDa). Fibers made of high molecular weight chitosans with adipic acid as the solvent generally exhibited higher tensile strength; the highest observed tensile strength and Young’s modulus were 308.0 ± 18.4 MPa and 22.7 ± 4.0 GPa, respectively. SEM images indicated the formation of cylindrical chitosan fibers. The survival (viability) of human skin fibroblasts in presence of different fibers was measured using tetrazolium-based colorimetric assay and results confirmed that chitosan fibers have better biocompatibility than common conventional sutures, regardless of the chitosan and acid type. Accordingly, chitosan fibers from fungal and shrimp sources serve as good candidates for application as sutures. |
| first_indexed | 2024-04-11T06:12:43Z |
| format | Article |
| id | doaj.art-16fc4abcd15240f7b9a1ccef6669615c |
| institution | Directory Open Access Journal |
| issn | 2590-2628 |
| language | English |
| last_indexed | 2024-04-11T06:12:43Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Biotechnology |
| spelling | doaj.art-16fc4abcd15240f7b9a1ccef6669615c2022-12-22T04:41:09ZengElsevierCurrent Research in Biotechnology2590-26282022-01-014530536Biocompatible fibers from fungal and shrimp chitosans for suture applicationNatacha Perrin0Ghasem Mohammadkhani1Farshad Homayouni Moghadam2Cédric Delattre3Akram Zamani4Swedish Centre for Resource Recovery, University of Borås, 501 90 Borås, SwedenSwedish Centre for Resource Recovery, University of Borås, 501 90 Borås, SwedenDepartment of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, 63000 Clermont-Ferrand, France; Institut Universitaire de France, Paris, FranceSwedish Centre for Resource Recovery, University of Borås, 501 90 Borås, Sweden; Corresponding author.Purified fungal chitosan and crustacean chitosan were wet spun by using adipic and lactic acids as solvent. The lowest viscosity at which fiber formation was possible was 0.5 Pa·s; below this value, aggregates from low molecular weight fungal chitosan (32 kDa) formed, which could not be collected and dried. Fiber formation was achieved with high molecular weight fungal (400 kDa) and shrimp (406.7 kDa) chitosans as well as low molecular weight shrimp chitosan (50–190 kDa). Fibers made of high molecular weight chitosans with adipic acid as the solvent generally exhibited higher tensile strength; the highest observed tensile strength and Young’s modulus were 308.0 ± 18.4 MPa and 22.7 ± 4.0 GPa, respectively. SEM images indicated the formation of cylindrical chitosan fibers. The survival (viability) of human skin fibroblasts in presence of different fibers was measured using tetrazolium-based colorimetric assay and results confirmed that chitosan fibers have better biocompatibility than common conventional sutures, regardless of the chitosan and acid type. Accordingly, chitosan fibers from fungal and shrimp sources serve as good candidates for application as sutures.http://www.sciencedirect.com/science/article/pii/S2590262822000442Fungal chitosanShrimp chitosanWet spinningAdipic acidLactic acidBiocompatibility |
| spellingShingle | Natacha Perrin Ghasem Mohammadkhani Farshad Homayouni Moghadam Cédric Delattre Akram Zamani Biocompatible fibers from fungal and shrimp chitosans for suture application Current Research in Biotechnology Fungal chitosan Shrimp chitosan Wet spinning Adipic acid Lactic acid Biocompatibility |
| title | Biocompatible fibers from fungal and shrimp chitosans for suture application |
| title_full | Biocompatible fibers from fungal and shrimp chitosans for suture application |
| title_fullStr | Biocompatible fibers from fungal and shrimp chitosans for suture application |
| title_full_unstemmed | Biocompatible fibers from fungal and shrimp chitosans for suture application |
| title_short | Biocompatible fibers from fungal and shrimp chitosans for suture application |
| title_sort | biocompatible fibers from fungal and shrimp chitosans for suture application |
| topic | Fungal chitosan Shrimp chitosan Wet spinning Adipic acid Lactic acid Biocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2590262822000442 |
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