MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis
Intravenous amphotericin B is a key component of the antifungal therapy for cryptococcal meningitis recommended in South African and international guidelines. Unfortunately, its use is associated with significant toxicity including deterioration in renal function, electrolyte disturbance, anaemia an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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AOSIS
2013-09-01
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| Series: | Southern African Journal of HIV Medicine |
| Subjects: | |
| Online Access: | https://sajhivmed.org.za/index.php/hivmed/article/view/70 |
| _version_ | 1811291121127522304 |
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| author | J Scriven J Cirota C Viljoen M Black G Meintjes |
| author_facet | J Scriven J Cirota C Viljoen M Black G Meintjes |
| author_sort | J Scriven |
| collection | DOAJ |
| description | Intravenous amphotericin B is a key component of the antifungal therapy for cryptococcal meningitis recommended in South African and international guidelines. Unfortunately, its use is associated with significant toxicity including deterioration in renal function, electrolyte disturbance, anaemia and infusion reactions. Chemical phlebitis is common following administration via peripheral cannulae. This can be complicated by bacterial infection, resulting in localised cellulitis or bacterial sepsis. Here we describe two patients with cryptococcal meningitis who developed methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia during, or shortly after treatment with amphotericin B. These cases illustrate the dangers of line-related sepsis in hospitalised individuals and some of the difficulties encountered during treatment of this condition. |
| first_indexed | 2024-04-13T04:23:44Z |
| format | Article |
| id | doaj.art-16fcf68f8eea4a4a9d11744b6afe4b8c |
| institution | Directory Open Access Journal |
| issn | 1608-9693 2078-6751 |
| language | English |
| last_indexed | 2024-04-13T04:23:44Z |
| publishDate | 2013-09-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of HIV Medicine |
| spelling | doaj.art-16fcf68f8eea4a4a9d11744b6afe4b8c2022-12-22T03:02:36ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512013-09-0114314414610.4102/sajhivmed.v14i3.7070MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitisJ Scriven0J Cirota1C Viljoen2M Black3G Meintjes4Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa; Liverpool School of Tropical Medicine, Liverpool, United KingdomDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, South AfricaDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, South AfricaDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South AfricaClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa; Department of Medicine, Imperial College London, United KingdomIntravenous amphotericin B is a key component of the antifungal therapy for cryptococcal meningitis recommended in South African and international guidelines. Unfortunately, its use is associated with significant toxicity including deterioration in renal function, electrolyte disturbance, anaemia and infusion reactions. Chemical phlebitis is common following administration via peripheral cannulae. This can be complicated by bacterial infection, resulting in localised cellulitis or bacterial sepsis. Here we describe two patients with cryptococcal meningitis who developed methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia during, or shortly after treatment with amphotericin B. These cases illustrate the dangers of line-related sepsis in hospitalised individuals and some of the difficulties encountered during treatment of this condition.https://sajhivmed.org.za/index.php/hivmed/article/view/70MRSAStaphylococcusamphotericin Bcryptococcal meningitis |
| spellingShingle | J Scriven J Cirota C Viljoen M Black G Meintjes MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis Southern African Journal of HIV Medicine MRSA Staphylococcus amphotericin B cryptococcal meningitis |
| title | MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis |
| title_full | MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis |
| title_fullStr | MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis |
| title_full_unstemmed | MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis |
| title_short | MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis |
| title_sort | mrsa bacteraemia complicating amphotericin b treatment of cryptococcal meningitis |
| topic | MRSA Staphylococcus amphotericin B cryptococcal meningitis |
| url | https://sajhivmed.org.za/index.php/hivmed/article/view/70 |
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