Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product
Purpose: Albendazole is the drug of choice for chemotherapy of cystic echinococcosis (CE) but 40% of patients do not respond to it satisfactorily. With regard to the previously reported scolicidal activity of Zataria multiflora, this study was done to evaluate the efficacy of the co-administration o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2017.1380089 |
| _version_ | 1797684521385066496 |
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| author | Mohammad Moazeni Hassan Borji Meysam Saboor Darbandi |
| author_facet | Mohammad Moazeni Hassan Borji Meysam Saboor Darbandi |
| author_sort | Mohammad Moazeni |
| collection | DOAJ |
| description | Purpose: Albendazole is the drug of choice for chemotherapy of cystic echinococcosis (CE) but 40% of patients do not respond to it satisfactorily. With regard to the previously reported scolicidal activity of Zataria multiflora, this study was done to evaluate the efficacy of the co-administration of albendazole and Z. multiflora aromatic water (AW) on hydatid cysts in a murine model. Materials and Methods: Laboratory mice were infected with 1,500 viable protoscoleces. After development of hydatid cysts, the infected mice were allocated into four treatment and one control group. The mice of groups 1, 2, 3, and 4 were treated orally with albendazole (100 mg/kg), Z. multiform AW (100 ml/l), albendazole (100 mg/kg) – Z. multiform AW and albendazole ((50 mg/kg) – Z. multiform AW respectively. Two months later, all the mice were euthanized and necropsied and the number, size and weight of hydatid cysts were compared between different groups. Results: The size of the largest cysts, as well as the total weight of cysts, were significantly lower (p < .05) in the mice treated with albendazole (50 mg/kg) – Z. multiflora AW in comparison to those treated with albendazole (100 mg/kg) alone. Conclusions: The results of this study revealed the superiority of co-administration of albendazole and Z. multiflora AW to albendazole alone in the treatment of CE in laboratory mice. Since Z. multiflora AW is a safe and useful drink, it may be used successfully to enhance the therapeutic effect of albendazole in the patients infected with hydatid disease. |
| first_indexed | 2024-03-12T00:31:53Z |
| format | Article |
| id | doaj.art-16fd2c8ee3b3471380a3484e6a71be9f |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:31:53Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-16fd2c8ee3b3471380a3484e6a71be9f2023-09-15T10:12:28ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532019-02-0132210311010.1080/08941939.2017.13800891380089Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal ProductMohammad Moazeni0Hassan Borji1Meysam Saboor Darbandi2School of Veterinary Medicine, Shiraz UniversitySchool of Veterinary Medicine, Ferdowsi University of MashhadSchool of Veterinary Medicine, Shiraz UniversityPurpose: Albendazole is the drug of choice for chemotherapy of cystic echinococcosis (CE) but 40% of patients do not respond to it satisfactorily. With regard to the previously reported scolicidal activity of Zataria multiflora, this study was done to evaluate the efficacy of the co-administration of albendazole and Z. multiflora aromatic water (AW) on hydatid cysts in a murine model. Materials and Methods: Laboratory mice were infected with 1,500 viable protoscoleces. After development of hydatid cysts, the infected mice were allocated into four treatment and one control group. The mice of groups 1, 2, 3, and 4 were treated orally with albendazole (100 mg/kg), Z. multiform AW (100 ml/l), albendazole (100 mg/kg) – Z. multiform AW and albendazole ((50 mg/kg) – Z. multiform AW respectively. Two months later, all the mice were euthanized and necropsied and the number, size and weight of hydatid cysts were compared between different groups. Results: The size of the largest cysts, as well as the total weight of cysts, were significantly lower (p < .05) in the mice treated with albendazole (50 mg/kg) – Z. multiflora AW in comparison to those treated with albendazole (100 mg/kg) alone. Conclusions: The results of this study revealed the superiority of co-administration of albendazole and Z. multiflora AW to albendazole alone in the treatment of CE in laboratory mice. Since Z. multiflora AW is a safe and useful drink, it may be used successfully to enhance the therapeutic effect of albendazole in the patients infected with hydatid disease.http://dx.doi.org/10.1080/08941939.2017.1380089cystic echinococcosisalbendazolezataria multifloraaromatic watertreatment |
| spellingShingle | Mohammad Moazeni Hassan Borji Meysam Saboor Darbandi Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product Journal of Investigative Surgery cystic echinococcosis albendazole zataria multiflora aromatic water treatment |
| title | Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product |
| title_full | Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product |
| title_fullStr | Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product |
| title_full_unstemmed | Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product |
| title_short | Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product |
| title_sort | enhancement of the therapeutic effect of albendazole on cystic echinococcosis using a herbal product |
| topic | cystic echinococcosis albendazole zataria multiflora aromatic water treatment |
| url | http://dx.doi.org/10.1080/08941939.2017.1380089 |
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