CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3′ Untranslated Region, Altering Polysome Association and Stress Tolerance in <italic toggle="yes">Cryptococcus neoformans</italic>

CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3′ Untranslated Region, Altering Polysome Association and Stress Tolerance in <italic toggle="yes">Cryptococcus neoformans</italic>

ABSTRACT In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and specifically repressed during cellular stress, and the bulk of this repression is mediated by deadenylation-dependent mRNA decay. A motif-finding approach was applied to the 3′ untranslated regions (UTRs) of...

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Bibliographic Details
Main Authors: Jay Leipheimer, Amanda L. M. Bloom, Tilman Baumstark, John C. Panepinto
Format: Article
Language:English
Published: American Society for Microbiology 2018-08-01
Series:mSphere
Subjects:
CNBP
G-quadruplex
posttranscriptional gene regulation
stress response
translation
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00201-18

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