Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue

Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue

On murine N2a cells, 7-ketocholesterol induced an oxiapotophagic mode of cell death characterized by oxidative stress (reactive oxygen species overproduction on whole cells and at the mitochondrial level; lipid peroxidation), apoptosis induction (caspase-9, −3 and −7 cleavage, PARP degradation) and...

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Bibliographic Details
Main Authors: Aline Yammine, Imen Ghzaiel, Vivien Pires, Amira Zarrouk, Omar Kharoubi, Hélène Greige-Gerges, Lizette Auezova, Gérard Lizard, Anne Vejux
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Toxicology
Subjects:
7-ketocholesterol
α-tocopherol
Eicosapentaenoic acid
α-linolenic acid
Oleic acid
glutathione peroxidase
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000069

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