Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications
Ethnopharmacology relevance:Dichondra repens J.R.Forst. and G.Forst (DRF; Convolvulaceae, called Matijin in Chinese), has been traditionally used to treat jaundice, bacillary dysentery, urinary tract infection, edema, contusions, and strains and sprains based on traditional Chinese medicine (TCM) co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.608199/full |
| _version_ | 1818870521309167616 |
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| author | Qi Yao Ying Wang Zhiyu Dong Chencen Lai Botao Chang Qiuju Gong Shuaijun Ren Dongxue Sun Jie Lu Ying Gao |
| author_facet | Qi Yao Ying Wang Zhiyu Dong Chencen Lai Botao Chang Qiuju Gong Shuaijun Ren Dongxue Sun Jie Lu Ying Gao |
| author_sort | Qi Yao |
| collection | DOAJ |
| description | Ethnopharmacology relevance:Dichondra repens J.R.Forst. and G.Forst (DRF; Convolvulaceae, called Matijin in Chinese), has been traditionally used to treat jaundice, bacillary dysentery, urinary tract infection, edema, contusions, and strains and sprains based on traditional Chinese medicine (TCM) concepts.Aim of study: This paper intends to provide a comprehensive and critical analysis of research on DRF focusing on a relationship between traditional uses and pharmacological effects, evaluating the therapeutic potential of this plant.Methods: Relevant data on DRF were retrieved from available databases.Results: The heat-clearing and detoxifying, and removing the phlegm and turbid urine effects of DRF are linked to its anti-hepatitis B virus (HBV), anti-inflammatory, and hepatoprotective activities. Especially, the hepatoprotective effects of DRF are mainly based on anti-HBV activities of phenylalanine dipeptides Matijin-Su (MTS) and its derivatives derived from this plant. Further, a phase I anti-HBV clinical trial of a candidate compound named bentysrepinine (Y101, Chinese name Tifentai) has been completed. Also, anti-tumor, analgesic, and antibacterial properties have been reported in the extracts and compounds from DRF. Although pharmacy, pharmacodynamics, toxicology, and pharmacokinetics of bentysrepinine have been systemically reported, no studies have reported chemistry, safety, pharmacology of other compounds or extracts systemically.Conclusion: Phenylalanine dipeptide compounds are main components and MTS is a characteristic substance of DRF. The main pharmacological effect of DRF is anti-HBV activity, which is coherent with the traditional use of this plant in China. Except bentysrepinine, few studies have been conducted on toxicities of the extracts or compounds from DRF. Thus, it is still necessary to evaluate safety, chemistry, pharmacology of the extracts or compounds from DRF regarding the link between traditional uses and modern applications before the future clinical trials. Bacterial sepsis, cholecystitis and tumors may be prior therapeutic targets of this plant in the future. |
| first_indexed | 2024-12-19T12:08:21Z |
| format | Article |
| id | doaj.art-16ffc4729dd848829c1af420e5c61975 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-19T12:08:21Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-16ffc4729dd848829c1af420e5c619752022-12-21T20:22:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-02-011110.3389/fphar.2020.608199608199Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and ApplicationsQi Yao0Ying Wang1Zhiyu Dong2Chencen Lai3Botao Chang4Qiuju Gong5Shuaijun Ren6Dongxue Sun7Jie Lu8Ying Gao9The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Gynaecology and Obstetrics, Taizhou Traditional Chinese Medicine Hospital, Taizhou, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaEthnopharmacology relevance:Dichondra repens J.R.Forst. and G.Forst (DRF; Convolvulaceae, called Matijin in Chinese), has been traditionally used to treat jaundice, bacillary dysentery, urinary tract infection, edema, contusions, and strains and sprains based on traditional Chinese medicine (TCM) concepts.Aim of study: This paper intends to provide a comprehensive and critical analysis of research on DRF focusing on a relationship between traditional uses and pharmacological effects, evaluating the therapeutic potential of this plant.Methods: Relevant data on DRF were retrieved from available databases.Results: The heat-clearing and detoxifying, and removing the phlegm and turbid urine effects of DRF are linked to its anti-hepatitis B virus (HBV), anti-inflammatory, and hepatoprotective activities. Especially, the hepatoprotective effects of DRF are mainly based on anti-HBV activities of phenylalanine dipeptides Matijin-Su (MTS) and its derivatives derived from this plant. Further, a phase I anti-HBV clinical trial of a candidate compound named bentysrepinine (Y101, Chinese name Tifentai) has been completed. Also, anti-tumor, analgesic, and antibacterial properties have been reported in the extracts and compounds from DRF. Although pharmacy, pharmacodynamics, toxicology, and pharmacokinetics of bentysrepinine have been systemically reported, no studies have reported chemistry, safety, pharmacology of other compounds or extracts systemically.Conclusion: Phenylalanine dipeptide compounds are main components and MTS is a characteristic substance of DRF. The main pharmacological effect of DRF is anti-HBV activity, which is coherent with the traditional use of this plant in China. Except bentysrepinine, few studies have been conducted on toxicities of the extracts or compounds from DRF. Thus, it is still necessary to evaluate safety, chemistry, pharmacology of the extracts or compounds from DRF regarding the link between traditional uses and modern applications before the future clinical trials. Bacterial sepsis, cholecystitis and tumors may be prior therapeutic targets of this plant in the future.https://www.frontiersin.org/articles/10.3389/fphar.2020.608199/fullDichondra repens forstchemistrypharmacologytoxicityApplications |
| spellingShingle | Qi Yao Ying Wang Zhiyu Dong Chencen Lai Botao Chang Qiuju Gong Shuaijun Ren Dongxue Sun Jie Lu Ying Gao Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications Frontiers in Pharmacology Dichondra repens forst chemistry pharmacology toxicity Applications |
| title | Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications |
| title_full | Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications |
| title_fullStr | Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications |
| title_full_unstemmed | Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications |
| title_short | Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications |
| title_sort | dichondra repens j r forst and g forst a review of its traditional uses chemistry pharmacology toxicology and applications |
| topic | Dichondra repens forst chemistry pharmacology toxicity Applications |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.608199/full |
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