Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism

Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism

The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists as multiple isoforms, including variants transcribed from an alternati...

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Main Authors: Kazuhiro Nomura, Shinichi Kinoshita, Nao Mizusaki, Yoko Senga, Tsutomu Sasaki, Tadahiro Kitamura, Hiroshi Sakaue, Aki Emi, Tetsuya Hosooka, Masahiro Matsuo, Hitoshi Okamura, Taku Amo, Alexander M. Wolf, Naomi Kamimura, Shigeo Ohta, Tomoo Itoh, Yoshitake Hayashi, Hiroshi Kiyonari, Anna Krook, Juleen R. Zierath, Masato Kasuga, Wataru Ogawa
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Molecular Metabolism
Subjects:
PGC-1α
Skeletal muscle
Exercise
Obesity
Diabetes
Energy expenditure
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000991

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http://www.sciencedirect.com/science/article/pii/S2212877824000991

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